Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.
Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.
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DOI：
10.1001/jamapsychiatry.2013.1180
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发表时间：
2013-05
期刊：
影响因子：
25.8
通讯作者：
Hultman, Christina M.
中科院分区：
文献类型：
--
作者：
Frans, Emma M.;Sandin, Sven;Reichenberg, Abraham;Langstrom, Niklas;Lichtenstein, Paul;McGrath, John J.;Hultman, Christina M.
父亲年龄的提前与自闭症有关。通过研究祖父年龄对儿童自闭症的影响，进一步扩大对父亲年龄与自闭症关系的认识。基于人群的多代病例对照研究。瑞典全国多代和患者登记。我们对自1932年以来在瑞典出生的人进行了研究。超过90%的队列获得了出生时的父母年龄。在一个较小的子集（5，936例病例和30，923例对照）中获得了父母出生时的祖父母年龄。国际疾病分类（ICD）诊断儿童自闭症的患者登记。有一个统计学显着单调的关联在祖父母出生时的年龄和风险自闭症的孙子。50岁以上才生女儿的男性为1.79倍（95%可信区间：1.35-2.37，p<0.001）更有可能生一个患有自闭症的孙子，而在50岁或更大年龄时生了一个儿子的男性是前者的1.67倍（95%置信区间：1.35-2.37，p<0.001）与20-24岁时有孩子的男性相比，在控制出生年份，性别，配偶年龄，精神疾病家族史后，最高的家庭教育和住宅县。父亲年龄的增加与后代患自闭症的风险之间也存在统计学显着的单调关联。敏感性分析表明，这些结果不是由于祖父母年龄数据缺失而导致的偏倚。祖父母年龄越大，患自闭症的风险越高，这表明自闭症的风险可能会在几代人之间发展。结果与与父亲年龄增长相关的突变和/或表观遗传改变一致。
Advancing paternal age has been linked to autism. To further expand knowledge about the relation between paternal age and autism by studying the effect of grandfathers’ age on childhood autism. Population-based multigenerational case-control study. Nationwide Multi-Generation and Patient registers in Sweden. We conducted a study of individuals born in Sweden since 1932. Parental age at birth was obtained for over 90% of the cohort. Grandparental age at the time of birth of the parent was obtained for a smaller subset (5,936 cases and 30,923 controls). International Classification of Diseases (ICD) diagnosis of childhood autism in the Patient Registry. There was a statistically significant monotonic association between advancing grandpaternal age at the time of birth of the parent and risk of autism in grandchildren. Men who had a daughter when they were 50 or older were 1.79 times (95% confidence interval: 1.35-2.37, p<0.001) more likely to have a grandchild with autism, and men who had a son when they were 50 or older were 1.67 times (95% confidence interval: 1.35-2.37, p<0.001) more likely to have a grandchild with autism, compared to men who had children when they were 20-24, after controlling for birth year, sex, age of the spouse, family history of psychiatric disorders, highest family education and residential county. There was also a statistically significant monotonic association between advancing paternal age and risk of autism in the offspring. Sensitivity analyses indicated that these findings were not the result of bias due to missing data on grandparental age. Advanced grandparental age was associated with increased risk of autism, suggesting that risk for autism could develop over generations. The results are consistent with mutations and/or epigenetic alterations associated with advancing paternal age.
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影响因子：
16.2
作者：
Iossifov I;Ronemus M;Levy D;Wang Z;Hakker I;Rosenbaum J;Yamrom B;Lee YH;Narzisi G;Leotta A;Kendall J;Grabowska E;Ma B;Marks S;Rodgers L;Stepansky A;Troge J;Andrews P;Bekritsky M;Pradhan K;Ghiban E;Kramer M;Parla J;Demeter R;Fulton LL;Fulton RS;Magrini VJ;Ye K;Darnell JC;Darnell RB;Mardis ER;Wilson RK;Schatz MC;McCombie WR;Wigler M
通讯作者：
Wigler M
影响因子：
5
作者：
Durkin, Maureen S.;Maenner, Matthew J.;Newschaffer, Craig J.;Lee, Li-Ching;Cunniff, Christopher M.;Daniels, Julie L.;Kirby, Russell S.;Leavitt, Lewis;Miller, Lisa;Zahorodny, Walter;Schieve, Laura A.
通讯作者：
Schieve, Laura A.
影响因子：
64.8
作者：
Kong A;Frigge ML;Masson G;Besenbacher S;Sulem P;Magnusson G;Gudjonsson SA;Sigurdsson A;Jonasdottir A;Jonasdottir A;Wong WS;Sigurdsson G;Walters GB;Steinberg S;Helgason H;Thorleifsson G;Gudbjartsson DF;Helgason A;Magnusson OT;Thorsteinsdottir U;Stefansson K
通讯作者：
Stefansson K
DOI：
10.1002/ajmg.1701
发表时间：
2002-04-08
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
Malaspina, D;Corcoran, C;Gorman, J
通讯作者：
Gorman, J
影响因子：
--
作者：
Frans, Emma M.;Sandin, Sven;Hultman, Christina M.
通讯作者：
Hultman, Christina M.