Advanced parental age and the risk of autism spectrum disorder.
Advanced parental age and the risk of autism spectrum disorder.
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DOI：
10.1093/aje/kwn250
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发表时间：
2008-12-01
影响因子：
5
通讯作者：
Schieve, Laura A.
中科院分区：
文献类型：
--
作者：
Durkin, Maureen S.;Maenner, Matthew J.;Newschaffer, Craig J.;Lee, Li-Ching;Cunniff, Christopher M.;Daniels, Julie L.;Kirby, Russell S.;Leavitt, Lewis;Miller, Lisa;Zahorodny, Walter;Schieve, Laura A.
这项研究评估了母亲和父亲年龄对自闭症谱系障碍风险的独立影响。使用来自美国疾病控制和预防中心自闭症和发育障碍监测网络的10个研究中心的数据进行病例队列设计。1994年出生队列包括253，347例研究中心出生的完整父母年龄信息。病例包括来自同一出生队列的1,251名8岁儿童，这些儿童具有完整的父母年龄信息，并根据精神疾病诊断和统计手册第四版文本修订标准被确定为患有自闭症谱系障碍。在调整了另一方父母的年龄、出生顺序、母亲的教育程度和其他协变量后，母亲和父亲的年龄都与自闭症独立相关（母亲年龄≥35岁与25-29岁的校正比值比= 1.3，95%置信区间：1.1，1.6;父亲年龄≥40岁与25-29岁的校正比值比= 1.4，95%置信区间：1.1，1.8）。2个年长父母的第一个孩子患自闭症的可能性是20-34岁母亲和40岁以下父亲的第三个或以后出生的孩子的3倍（比值比= 3.1，95%置信区间：2.0，4.7）。随着母亲和父亲年龄的增加，孤独症风险增加，这对公共卫生规划和孤独症病因学调查有潜在的影响。
This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age ≥35 vs. 25–29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age ≥40 years vs. 25–29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20–34 years and fathers aged <40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology.
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