Influence of beta-Endorphin on anxious behavior in mice: interaction with EtOH.
Influence of beta-Endorphin on anxious behavior in mice: interaction with EtOH.
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DOI：
10.1007/s00213-008-1161-4
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发表时间：
2008-09
影响因子：
3.4
通讯作者：
Turgeon, Victoria L.
中科院分区：
文献类型：
--
作者：
Grisel, Judith E.;Bartels, Jessica L.;Allen, Stephani A.;Turgeon, Victoria L.
阿片肽 β-内啡肽 (β-E) 由阿片黑皮质素原基因合成，以响应环境压力源和饮酒，并与这些刺激相关的行为后遗症有关。我们试图通过使用与 β-E 不同的转基因小鼠评估焦虑的基础测量以及 EtOH 诱导的抗焦虑行为，来确定 β-E 对应激反应的影响。使用明暗盒和十字迷宫测定法评估雄性和雌性杂合子、野生型和 β-E 敲除小鼠的焦虑行为。随后的测试评估腹腔内盐水或乙醇（0.5、1.0 和 1.5 g/kg）给药 20 分钟后的行为。我们观察到 β-E 水平与进入 Plus Maze 的开放臂的百分比以及在基础条件下在明暗盒的开放臂或光室中花费的时间之间存在反比关系，表明这种肽通常会抑制焦虑行为。然而，在这些测定中，缺乏 β-E 的小鼠表现出对乙醇的过度抗焦虑反应。这些数据表明，β-E 可以调节对压力刺激的反应，并支持这种肽影响乙醇行为效应的假设。
The opioid peptide β-endorphin (β-E) is synthesized by the pro-opiomelanocortin gene in response to environmental stressors and alcohol administration and is implicated in the behavioral sequelae associated with these stimuli. We sought to determine the influence of β-E on the stress response by evaluating basal measures of anxiety as well as on EtOH-induced anxiolytic behavior using transgenic mice that differ with respect to β-E. Anxious behavior was evaluated for male and female heterozygous, wild type, and β-E knockout mice using the Light-Dark Box and Plus Maze assays. Subsequent tests evaluated behavior 20 min after administration of intraperitoneal saline or EtOH (0.5, 1.0 and 1.5 g/kg). We observed an inverse relationship between β-E levels and the percentage of entries into open arms of the Plus Maze as well as the time spent in either the open arms or the light compartment of the Light-Dark box during basal conditions, suggesting that this peptide normally inhibits anxious behavior. However, mice lacking β-E demonstrated an exaggerated anxiolytic response to EtOH in these assays. These data suggest that β-E moderates the response to stressful stimuli and supports the hypothesis that this peptide influences the behavioral effects of EtOH.
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影响因子：
4.8
作者：
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通讯作者：
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DOI：
10.1111/j.1530-0277.2007.00396.x
发表时间：
2007-07-01
影响因子：
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