Role of homocysteine in the development of cardiovascular disease.
Role of homocysteine in the development of cardiovascular disease.
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DOI：
10.1186/1475-2891-14-6
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发表时间：
2015-01-10
影响因子：
5.4
通讯作者：
Alam SF
中科院分区：
文献类型：
--
作者：
Ganguly P;Alam SF
众所周知，中风后的神经元损伤归因于兴奋性氨基酸如谷氨酸和天冬氨酸通过激活NMDA受体的过度刺激。脑暴露于血浆的大部分成分，包括高半胱氨酸，这是中风、头部创伤和压力后血脑屏障破坏的结果。因此，问题是同型半胱氨酸是否能够选择性地刺激兴奋性氨基酸的释放。这篇综述文章将讨论同型半胱氨酸在神经系统中的重要性，特别是这些氨基酸如何触发儿茶酚胺的释放。因此，我们的数据将加强这样一种观点，即高同型半胱氨酸血症与卒中时脑损伤增加相关的机制。由于下丘脑也通过交感神经系统控制心脏功能，心脏的收缩力会受到影响。还已知同型半胱氨酸通过其对心血管内皮细胞和平滑肌细胞的不利影响介导心血管问题，导致亚临床动脉结构和功能的改变。因此，本综述将总结同型半胱氨酸的中枢和外周效应，并将突出一些与高同型半胱氨酸血症引起的心血管问题的争议。
It is well known that neuronal damage following a stroke has been attributed to the over stimulation of excitatory amino acids such as glutamate and aspartate through activation of NMDA receptors. The brain is exposed to most of the constituents of plasma including homocysteine as a result of the disruption of the blood–brain barrier after stroke, head trauma and stress. The question, therefore, arises as to whether or not homocysteine is able to selectively stimulate the release of excitatory amino acids in stroke. This review article will address the importance of homocysteine in nervous system specifically how these amino acids may trigger the release of catecholamines. Our data will thus strengthen the view that a mechanism for the association of hyperhomocysteinemia with increased brain lesion in stroke. As hypothalamus also controls the cardiac function via sympathetic system, the contractility of heart will be compromised. Homocysteine is also known to mediate cardiovascular problems by its adverse effects on cardiovascular endothelium and smooth muscle cells with resultant alterations in subclinical arterial structure and function. The present review will thus summarize both central and peripheral effects of homocysteine and will highlight some of the controversies associated with hyperhomocysteinemia-induced cardiovascular problems.
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影响因子：
0.3
作者：
Baszczuk, Aleksandra;Kopczynski, Zygmunt
通讯作者：
Kopczynski, Zygmunt
影响因子：
5.3
作者：
Pang, Xiaoming;Liu, Juntian;Wu, Di
通讯作者：
Wu, Di
老年人血清同型半胱氨酸与动脉僵硬度之间的关联：一项基于社区的研究
DOI：
10.3969/j.issn.1671-5411.2014.01.007
发表时间：
2014-03
期刊：
Journal of geriatric cardiology : JGC
影响因子：
--
作者：
Zhang S;Bai YY;Luo LM;Xiao WK;Wu HM;Ye P
通讯作者：
Ye P
影响因子：
4.6
作者：
Okura T;Miyoshi K;Irita J;Enomoto D;Nagao T;Kukida M;Tanino A;Kudo K;Pei Z;Higaki J
通讯作者：
Higaki J
影响因子：
7.5
作者：
Schaffer, Alon;Verdoia, Monica;De Luca, Giuseppe
通讯作者：
De Luca, Giuseppe