Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development.
Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line ganglia development.
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DOI：
10.1002/dvdy.22665
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发表时间：
2011-07
影响因子：
2.5
通讯作者：
Marrs, J. A.
中科院分区：
文献类型：
--
作者：
Liu, Q.;Dalman, M. R.;Sarmah, S.;Chen, S.;Chen, Y.;Hurlbut, A. K.;Spencer, M. A.;Pancoe, L.;Marrs, J. A.
钙粘蛋白调节脊椎动物神经系统的发育。我们以前的研究表明，钙粘蛋白-6信使（cdh 6）强烈表达在大多数胚胎斑马鱼颅和侧线神经节在其发展。在这里，我们提出的证据表明，cdh 6在颅侧神经节和神经发育过程中具有特定的功能。我们分析了cdh 6功能缺失对斑马鱼胚胎颅神经节和神经分化的影响。用斑马鱼cdh 6特异性反义吗啉代寡核苷酸（MO，其在发育期间抑制基因表达; cdh 6吗啉代胚胎）注射的胚胎显示出特定的表型，包括（i）改变的形状和减少的颅和侧线神经节（例如，听神经节和迷走神经节）的子集的发育和（ii）颅神经异常形成。这些数据说明了cdh 6在颅神经节及其神经的形成中的重要作用。
Cadherins regulate the vertebrate nervous system development. We previously showed that cadherin-6 message (cdh6) was strongly expressed in the majority of the embryonic zebrafish cranial and lateral line ganglia during their development. Here, we present evidence that cdh6 has specific functions during cranial and lateral line ganglia and nerve development. We analyzed the consequences of cdh6 loss-of-function on cranial ganglion and nerve differentiation in zebrafish embryos. Embryos injected with zebrafish cdh6 specific antisense morpholino oligonucleotides (MOs, which suppress gene expression during development; cdh6 morphant embryos) displayed a specific phenotype, including (i) altered shape and reduced development of a subset of the cranial and lateral line ganglia (e.g. the statoacoustic ganglion and vagal ganglion) and (ii) cranial nerves were abnormally formed. This data illustrates an important role for cdh6 in the formation of cranial ganglia and their nerves.
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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