Gut microbiota development during infancy: Impact of introducing allergenic foods.
Gut microbiota development during infancy: Impact of introducing allergenic foods.
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婴儿期肠道菌群的发展：引入过敏性食物的影响。
DOI：
10.1016/j.jaci.2020.09.042
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发表时间：
2021-03
影响因子：
14.2
通讯作者：
Flohr, Carsten
中科院分区：
文献类型：
--
作者：
Marrs, Tom;Jo, Jay-Hyun;Perkin, Michael R.;Rivett, Damian W.;Witney, Adam A.;Bruce, Kenneth D.;Logan, Kirsty;Craven, Joanna;Radulovic, Suzana;Versteeg, Serge A.;van Ree, Ronald;McLean, W. H. Irwin;Strachan, David P.;Lack, Gideon;Kong, Heidi H.;Flohr, Carsten
肠道菌群在婴儿早期期间的免疫学教育中可能起重要作用。
我们试图确定婴儿肠道菌群在婴儿期期间如何发展，尤其是与卫生相关的环境因素，特应性疾病以及过敏固体的随机引入。
从3个月大的饮食随机对照试验（询问耐受性研究），总共有1303名专门母乳喂养的婴儿参加。在这项嵌套的纵向研究中，使用16S核糖体RNA基因基因基因测序时，在基线时收集了粪便样品，并在6和12个月时对选定病例和对照进行了额外的采样，以研究其肠道菌群的演变。
在3个月的独家母乳喂养的婴儿的288个基线样品中，肠道菌群高度异质，形成了3种不同的簇：富含双歧杆菌，富含细菌和富含菌群/志贺氏菌。交付方式是主要的区别因素。在3个月时，在3个月中的特应性皮炎的存在时，Sensu严格的相对丰度增加了3个月和12个月的检查。从纵向样品（n = 70）的选定病例和对照中，在生命的第一年中观察到了富含细菌的群落和成人特异性微生物的过渡。与推荐的婴儿相比，过敏固体的引入促进了香农多样性和特定微生物的代表性显着增加，例如属于Prevotellaceae和proteeobacteria（例如，Escherichia/Shigella）的属，与建议独家乳腺癌相比。
来自3个月大母乳喂养的婴儿样品的特定肠道微生物群与剖宫产有关，并且较大的梭状芽孢杆菌严格丰度与特应性皮炎有关。从3个月开始的过敏固体随机引入与母乳喂养以及肠道微生物群落成熟的差异动态有关。
The gut microbiota potentially plays an important role in the immunologic education of the host during early infancy. We sought to determine how the infant gut microbiota evolve during infancy, particularly in relation to hygiene-related environmental factors, atopic disorders, and a randomized introduction of allergenic solids. A total of 1303 exclusively breast-fed infants were enrolled in a dietary randomized controlled trial (Enquiring About Tolerance study) from 3 months of age. In this nested longitudinal study, fecal samples were collected at baseline, with additional sampling of selected cases and controls at 6 and 12 months to study the evolution of their gut microbiota, using 16S ribosomal RNA gene-targeted amplicon sequencing. In the 288 baseline samples from exclusively breast-fed infant at 3 months, the gut microbiota was highly heterogeneous, forming 3 distinct clusters: Bifidobacterium-rich, Bacteroides-rich, and Escherichia/Shigella-rich. Mode of delivery was the major discriminating factor. Increased Clostridium sensu stricto relative abundance at 3 months was associated with presence of atopic dermatitis on examination at age 3 and 12 months. From the selected cases and controls with longitudinal samples (n = 70), transition to Bacteroides-rich communities and influx of adult-specific microbes were observed during the first year of life. The introduction of allergenic solids promoted a significant increase in Shannon diversity and representation of specific microbes, such as genera belonging to Prevotellaceae and Proteobacteria (eg, Escherichia/Shigella), as compared with infants recommended to exclusively breast-feed. Specific gut microbiota characteristics of samples from 3-month-old breast-fed infants were associated with cesarean birth, and greater Clostridium sensu stricto abundance was associated with atopic dermatitis. The randomized introduction of allergenic solids from age 3 months alongside breast-feeding was associated with differential dynamics of maturation of the gut microbial communities.
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影响因子：
16.6
作者：
Jackson MA;Verdi S;Maxan ME;Shin CM;Zierer J;Bowyer RCE;Martin T;Williams FMK;Menni C;Bell JT;Spector TD;Steves CJ
通讯作者：
Steves CJ
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob