Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins.
Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins.
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DOI：
10.18632/oncotarget.2108
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发表时间：
2014-06-30
期刊：
影响因子：
--
通讯作者：
Gustavson MD
中科院分区：
文献类型：
--
作者：
O'Shannessy DJ;Somers EB;Chandrasekaran LK;Nicolaides NC;Bordeaux J;Gustavson MD
肿瘤细胞和基质微环境之间的相互作用影响肿瘤的存活。一个实例是内皮唾液酸蛋白（肿瘤内皮标志物-1（TEM-1）或CD 248），其主要由间充质来源的细胞和一些肿瘤细胞表达。作为结构掩蔽的函数，TEM-1及其通路相关蛋白的表达被定量并检查与结肠直肠癌（CRC）队列的五年疾病特异性存活率的关联，所述结肠直肠癌（CRC）队列被分为训练（n=330）和验证（n=164）集。尽管TEM-1的基质表达具有预后价值，但通过线性组合5个区室特异性表达评分（TEM-1基质、TEM-1肿瘤血管、HIF 2 α基质血管、IV型胶原肿瘤和纤连蛋白基质）获得了更显著的预后特征。这导致了一个单一的连续风险评分（TAPPS：TEM-1相关通路预后特征），其与训练集[HR=1.76（95%CI：1.44-2.15）; p<0.001]和验证集[HR=1.38（95%CI：1.02-1.88）; p=0.04]的生存率降低显著相关。重要的是，由于预后是II期患者的关键临床问题，因此TAPPS评分还显著预测了II期患者（n=126）队列的生存率[HR=1.75（95%CI：1.22-2.52）; p=0.002]，这表明使用TAPPS评分评估CRC患者，特别是II期患者的总体风险的潜力。
Tumor survival is influenced by interactions between tumor cells and the stromal microenvironment. One example is Endosialin (Tumor Endothelial Marker-1 (TEM-1) or CD248), which is expressed primarily by cells of mesenchymal origin and some tumor cells. The expression, as a function of architectural masking, of TEM-1 and its pathway-associated proteins was quantified and examined for association with five-year disease-specific survival on a colorectal cancer (CRC) cohort divided into training (n=330) and validation (n=164) sets. Although stromal expression of TEM-1 had prognostic value, a more significant prognostic signature was obtained through linear combination of five compartment-specific expression scores (TEM-1 Stroma, TEM-1 Tumor Vessel, HIF2α Stromal Vessel, Collagen IV Tumor, and Fibronectin Stroma). This resulted in a single continuous risk score (TAPPS: TEM-1 Associated Pathway Prognostic Signature) which was significantly associated with decreased survival on both the training set [HR=1.76 (95%CI: 1.44-2.15); p<0.001] and validation set [HR=1.38 (95%CI: 1.02-1.88); p=0.04]. Importantly, since prognosis is a critical clinical question in Stage II patients, the TAPPS score also significantly predicted survival in the Stage II patient (n=126) cohort [HR=1.75 (95%CI: 1.22-2.52); p=0.002] suggesting the potential of using the TAPPS score to assess overall risk in CRC patients, and specifically in Stage II patients.
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影响因子：
3.8
作者：
Maia M;DeVriese A;Janssens T;Moons M;Lories RJ;Tavernier J;Conway EM
通讯作者：
Conway EM
DOI：
10.1073/pnas.90.2.393
发表时间：
1993-01-15
影响因子：
11.1
作者：
FORSBERG, K;VALYINAGY, I;WESTERMARK, B
通讯作者：
WESTERMARK, B
影响因子：
45.3
作者：
Camp, Robert L.;Neumeister, Veronique;Rimm, David L.
通讯作者：
Rimm, David L.
影响因子：
5.4
作者：
Lax, Sian;Hardie, Debbie L.;Wilson, Amy;Douglas, Mike R.;Anderson, Graham;Huso, David;Isacke, Clare M.;Buckley, Christopher D.
通讯作者：
Buckley, Christopher D.
DOI：
10.1073/pnas.0511306103
发表时间：
2006-02-28
影响因子：
11.1
作者：
Nanda, A;Karim, B;Huso, DL
通讯作者：
Huso, DL