Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases.
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases.
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DOI：
10.1186/s12974-022-02637-1
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发表时间：
2022-11-17
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
--
作者：
小胶质细胞代表大脑中免疫反馈的第一道防线。除了免疫监视之外，它们对于维持大脑稳态至关重要。最近的研究揭示了小胶质细胞的时空异质性，基于其局部和基于时间的功能，在脑创伤或疾病时，内稳态被破坏。在生理状态和脑损伤中记录了不同的“小胶质细胞特征”，具有离散或有时重叠的促炎和抗炎功能。小胶质细胞参与神经修复过程，如神经血管单位的恢复和突触可塑性，并管理由于其表型转换造成的损伤程度。细胞表型的多样性超出了经典的M1/M2分类，以及小胶质细胞在神经变性中的双刃作用，表明需要进一步探索小胶质细胞的动力学及其对神经变性过程的贡献。这篇综述讨论了不同的小胶质细胞亚群的自我平衡功能，侧重于神经病理条件。此外，我们还讨论了靶向小胶质细胞作为神经退行性疾病治疗策略的可行性。
Microglia represent the first line of immune feedback in the brain. Beyond immune surveillance, they are essential for maintaining brain homeostasis. Recent research has revealed the microglial cells' spatiotemporal heterogeneity based on their local and time-based functions in brain trauma or disease when homeostasis is disrupted. Distinct "microglial signatures" have been recorded in physiological states and brain injuries, with discrete or sometimes overlapping pro- and anti-inflammatory functions. Microglia are involved in the neurological repair processes, such as neurovascular unit restoration and synaptic plasticity, and manage the extent of the damage due to their phenotype switching. The versatility of cellular phenotypes beyond the classical M1/M2 classification, as well as the double-edge actions of microglia in neurodegeneration, indicate the need for further exploration of microglial cell dynamics and their contribution to neurodegenerative processes. This review discusses the homeostatic functions of different microglial subsets focusing on neuropathological conditions. Also, we address the feasibility of targeting microglia as a therapeutic strategy in neurodegenerative diseases.
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耦合的增殖和凋亡维持成人大脑中小胶质细胞的快速离职。
影响因子：
8.8
作者：
Askew K;Li K;Olmos-Alonso A;Garcia-Moreno F;Liang Y;Richardson P;Tipton T;Chapman MA;Riecken K;Beccari S;Sierra A;Molnár Z;Cragg MS;Garaschuk O;Perry VH;Gomez-Nicola D
通讯作者：
Gomez-Nicola D
影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
5.7
作者：
Albertson, Asher J.;Landsness, Eric C.;Tang, Michelle J.;Yan, Ping;Miao, Hanyang;Rosenthal, Zachary P.;Kim, Byungchan;Culver, Joseph C.;Bauer, Adam Q.;Lee, Jin-Moo
通讯作者：
Lee, Jin-Moo
影响因子：
12.7
作者：
Boza-Serrano, Antonio;Ruiz, Rocio;Deierborg, Tomas
通讯作者：
Deierborg, Tomas
影响因子：
7.3
作者：
Andoh M;Koyama R
通讯作者：
Koyama R