Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity.
Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity.
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DOI：
10.1016/j.neuroimage.2022.119287
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发表时间：
2022-08-15
期刊：
影响因子：
5.7
通讯作者：
Lee, Jin-Moo
中科院分区：
文献类型：
--
作者：
Albertson, Asher J.;Landsness, Eric C.;Tang, Michelle J.;Yan, Ping;Miao, Hanyang;Rosenthal, Zachary P.;Kim, Byungchan;Culver, Joseph C.;Bauer, Adam Q.;Lee, Jin-Moo
正常衰老与各种神经系统变化有关，包括认知、记忆和运动活动下降。这些下降与神经元突触结构和功能的变化相关。大脑网络活动和连接性的退化可能是这些神经元变化导致的与年龄相关的功能退化的中介因素。人类研究表明，随着年龄的增长，自发皮质活动普遍减少，皮质网络受到破坏。目前用于研究大脑网络活动的技术要么受到有限的空间分辨率（例如脑电图、EEG）或有限的时间分辨率（例如功能磁共振成像、fMRI）的限制。在这里，我们利用 Thy1-GCaMP6f 小鼠神经元活动的中尺度成像来表征衰老过程中神经元网络的变化，在较宽的频率范围内具有高空间分辨率。我们发现，虽然诱发活动随着年龄的增长而不变，但自发神经元活动在涉及皮层所有区域的宽频率范围（0.01-4 Hz）内下降。与皮质能力的整体下降相反，我们发现衰老与特定网络（包括躯体运动、扣带回和压后节点）的功能连接（FC）恶化有关。这些变化通过躯体运动和视觉皮层内同位 FC 和节点度的减少得到证实。最后，我们发现全皮层 delta 功率和 delta 带节点程度与年轻动物的探索活动相关，但与老年动物无关。这些数据共同表明，衰老与自发皮质活动的整体下降和网络连接的局部恶化有关，并且这些下降可能与与年龄相关的行为下降有关。
Normal aging is associated with a variety of neurologic changes including declines in cognition, memory, and motor activity. These declines correlate with neuronal changes in synaptic structure and function. Degradation of brain network activity and connectivity represents a likely mediator of age-related functional deterioration resulting from these neuronal changes. Human studies have demonstrated both general decreases in spontaneous cortical activity and disruption of cortical networks with aging. Current techniques used to study cerebral network activity are hampered either by limited spatial resolution (e.g. electroencephalography, EEG) or limited temporal resolution (e.g., functional magnetic resonance imaging, fMRI). Here we utilize mesoscale imaging of neuronal activity in Thy1-GCaMP6f mice to characterize neuronal network changes in aging with high spatial resolution across a wide frequency range. We show that while evoked activity is unchanged with aging, spontaneous neuronal activity decreases across a wide frequency range (0.01–4 Hz) involving all regions of the cortex. In contrast to this global reduction in cortical power, we found that aging is associated with functional connectivity (FC) deterioration of select networks including somatomotor, cingulate, and retrosplenial nodes. These changes are corroborated by reductions in homotopic FC and node degree within somatomotor and visual cortices. Finally, we found that whole-cortex delta power and delta band node degree correlate with exploratory activity in young but not aged animals. Together these data suggest that aging is associated with global declines in spontaneous cortical activity and focal deterioration of network connectivity, and that these reductions may be associated with age-related behavioral declines.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Avelar-Pereira B;Bäckman L;Wåhlin A;Nyberg L;Salami A
通讯作者：
Salami A
影响因子：
25
作者：
通讯作者：
--
DOI：
10.1523/jneurosci.5845-11.2012
发表时间：
2012-03-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bero AW;Bauer AQ;Stewart FR;White BR;Cirrito JR;Raichle ME;Culver JP;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
3.3
作者：
Dickstein, D. L.;Weaver, C. M.;Luebke, J. I.;Hof, P. R.
通讯作者：
Hof, P. R.