Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors: An RDSafe Study.
Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors: An RDSafe Study.
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DOI：
10.1016/j.bbmt.2020.08.016
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Pulsipher MA
中科院分区：
文献类型：
--
作者：
Switzer GE;Bruce JG;Kiefer DM;Kobusingye H;Abebe KZ;Drexler R;Besser RM;Confer DL;Horowitz MM;King RJ;Shaw BE;Riches M;Hayes-Lattin B;Linenberger M;Bolwell B;Rowley SD;Litzow MR;Pulsipher MA
多项调查记录了无关捐赠者的健康相关生活质量 (HRQoL) 和捐赠相关经历 (URD)，但对相关捐赠者 (RD) 经历的类似调查并不常见。本研究的中心目标是纵向检查和比较 RD 和 URD HSC 捐赠者从捐赠前到捐赠后 1 年的 HRQoL。这项前瞻性调查包括 18-60 岁的成年 HSC 捐献者，他们在 48 个不同地理位置的美国移植/捐献中心之一捐献骨髓或外周血干细胞，并在捐献前、捐献后 4 周和 1 年完成 HRQoL 访谈。在捐赠前，与 URD 相比，相关捐赠者对捐赠的矛盾情绪较少 (t=−3.30；p=.001)，对自己的捐赠决定更加满意 (t=2.65；p=.009)，并且更有可能将自己定义为捐赠者 (t=2.94；p=.004)。然而，相关捐赠者更关心针头的使用（OR=2.19；p=.012）、谁来支付手术费用（OR=2.80；p=.011），以及如果移植失败他们是否会感到有责任（t=2.31；p=.022）。捐赠后不久，相关捐赠者更有可能报告捐赠相关的疼痛（t=2.50；p=.013）和头晕（OR=3.63；p=.028）。捐赠后 1 年，相关捐赠者从捐赠中完全恢复的可能性较小 (OR=0.10；p=.010)，并且更有可能报告捐赠后恢复期较长 (t=2.57；p=.011)，尽管后一发现主要是由于相关捐赠者与非相关捐赠者在一年后未完全康复的百分比（10% 与 1%）有关。总而言之，这些研究结果表明，当前的相关捐赠者管理实践可能足以让相关捐赠者做好捐赠心理方面的准备，但在校准相关捐赠者群体的捐赠相关经历和恢复时间的描述方面可能还有更多工作要做——即，基于无关捐赠的捐赠经历描述可能无法提供对该群体经历的最佳估计。
Multiple investigations have documented the health-related quality-of-life (HRQoL) and donation-related experiences of unrelated donors (URD), but similar investigations of the related-donor (RD) experience have been less common. The central goal of this study was to longitudinally examine and compare HRQoL of RD and URD HSC donors from pre-donation through 1 year post-donation. This prospective investigation included adult HSC donors ages 18–60, who donated bone marrow or peripheral blood stem cells at one of 48 geographically diverse US transplant/donor centers and completed HRQoL interviews at predonation, and 4 weeks and 1 year post-donation. At predonation, related donors were less ambivalent about donation (t=−3.30; p=.001), more satisfied with their decision to donate (t=2.65; p=.009), and more likely to define themselves as donors (t=2.94; p=.004) than were URD. However, related donors were more concerned about the use of needles (OR=2.19; p=.012), about who would pay for the procedure (OR=2.80; p=.011), and the possibility that they would feel responsible if the transplant failed (t=2.31; p=.022). Shortly post-donation, related donors were more likely to report donation-related pain (t=2.50; p=.013) and lightheadedness (OR=3.63; p=.028). At 1 year post-donation, related donors were less likely to be fully recovered from donation (OR=0.10; p=.010) and more likely to report a longer recovery period following donation (t=2.57; p=.011), although this latter finding was primarily due to the percent of related versus unrelated donors not fully recovered at 1-year post (10% versus 1%). Taken together, these findings suggest that current related donor management practices may be sufficient in preparing related donors for the psychological aspects of donation but that there may be more to do in terms of calibrating the description of donation-related experiences and recovery time to the related donor group - i.e., descriptions of donation experiences based on unrelated donation may not provide best estimates of experience for this group.
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影响因子：
4.3
作者：
Switzer, Galen E.;Bruce, Jessica G.;Wingard, John R.
通讯作者：
Wingard, John R.
影响因子：
2.5
作者：
Switzer, GE;Simmons, RG;Dew, MA
通讯作者：
Dew, MA
DOI：
10.1002/bs.3830190102
发表时间：
1974-01-01
期刊：
BEHAVIORAL SCIENCE
影响因子：
--
作者：
DEROGATIS, LR;LIPMAN, RS;COVI, L
通讯作者：
COVI, L
影响因子：
4.3
作者：
Pulsipher, Michael A.;Logan, Brent R.;Switzer, Galen E.
通讯作者：
Switzer, Galen E.
影响因子：
20.3
作者：
Hoelig, Kristina;Kramer, Michael;Ehninger, Gerhard
通讯作者：
Ehninger, Gerhard