Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs.
Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs.
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基于导管的射频肾交感神经去神经术可减少高血压犬的左心室肥大
DOI：
10.1155/2021/9938486
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发表时间：
2021
影响因子：
4.6
通讯作者：
Zhang ZH
中科院分区：
文献类型：
--
作者：
Tu S;Shen ZJ;Wang XY;Zeng LX;Zhang ZH
本研究探讨了去肾交感神经（RDN）对高脂血症诱导的比格犬心脏肥大的影响。将60只比格犬随机分为对照组、RDN组和假手术组。对照组给予基础饲料喂养，其余两组给予高脂饲料喂养，建立高血压模型。RDN组行RDN手术，假手术组仅行肾动脉造影。术后1、3、6个月，RDN组舒张压（DBP）和收缩压（SBP）均较假手术组显著降低（P < 0.05）。6个月后，RDN组血清去甲肾上腺素（NE）、血管紧张素II（AngII）及左心室水平均低于假手术组（P < 0.05）。左室重量（LVM）和左室重量指数（LVMI）明显降低，E/A峰值比值明显升高（P < 0.05）。病理检查显示，与假手术组相比，RDN组左室肥厚和纤维化程度明显减轻，胶原体积分数（CVF）和血管周胶原面积（PVCA）也明显减少（P < 0.05）。去肾交感神经不仅能有效降低高血压犬的血压水平，而且能减轻左室肥厚和心肌纤维化，改善左室舒张功能。其机制可能与循环和心肌组织中NE和AngII水平降低有关，从而导致左室重构延迟发生。
This study explored the effects of renal sympathetic denervation (RDN) on hyperlipidity-induced cardiac hypertrophy in beagle dogs. Sixty beagles were randomly assigned to the control group, RDN group, or sham-operated group. The control group was fed with a basal diet, while the other two groups were given a high-fat diet to induce model hypertension. The RDN group underwent an RDN procedure, and the sham-operated group underwent only renal arteriography. At 1, 3, and 6 months after the RDN procedure, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) levels were markedly decreased in the RDN group relative to the sham group (P < 0.05). After 6 months, serum norepinephrine (NE) and angiotensin II (AngII), as well as left ventricular levels, in the RDN group were statistically lower than those in the sham group (P < 0.05). Also, the left ventricular mass (LVM) and left ventricular mass index (LVMI) were significantly decreased, while the E/A peak ratio was drastically elevated (P < 0.05). Pathological examination showed that the degree of left ventricular hypertrophy and fibrosis in the RDN group was statistically decreased relative to those of the sham group and that the collagen volume fraction (CVF) and perivascular circumferential collagen area (PVCA) were also significantly reduced (P < 0.05). Renal sympathetic denervation not only effectively reduced blood pressure levels in hypertensive dogs but also reduced left ventricular hypertrophy and myocardial fibrosis and improved left ventricular diastolic function. The underlying mechanisms may involve a reduction of NE and AngII levels in the circulation and myocardial tissues, which would lead to the delayed occurrence of left ventricular remodeling.
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DOI：
10.1016/s0140-6736(21)00516-x
发表时间：
2021-03-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2019 Hearing Loss Collaborators
通讯作者：
GBD 2019 Hearing Loss Collaborators
影响因子：
6
作者：
Hopper, Ingrid;Gronda, Edoardo;Krum, Henry
通讯作者：
Krum, Henry
影响因子：
5.4
作者：
Li X;Lu Q;Qiu Y;do Carmo JM;Wang Z;da Silva AA;Mouton A;Omoto ACM;Hall ME;Li J;Hall JE
通讯作者：
Hall JE
影响因子：
24
作者：
Brandt, Mathias C.;Mahfoud, Felix;Hoppe, Uta C.
通讯作者：
Hoppe, Uta C.
影响因子：
5.4
作者：
Domingos-Souza, Gean;Santos-Almeida, Fernanda Machado;Fazan Jr, Rubens
通讯作者：
Fazan Jr, Rubens