Urinary triclosan is associated with elevated body mass index in NHANES.
Urinary triclosan is associated with elevated body mass index in NHANES.
复制标题
DOI：
10.1371/journal.pone.0080057
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Parsonnet J
中科院分区：
文献类型：
--
作者：
Lankester J;Patel C;Cullen MR;Ley C;Parsonnet J
三氯生是牙膏、肥皂和家用清洁剂中普遍存在的一种化学物质，它有可能改变肠道菌群和内分泌功能，从而影响体重。我们使用2003-2008年的国家健康和营养检查调查（NHANES）调查了三氯生与体重指数（BMI）之间的关系。从成人中获得BMI和尿液三氯生水平。使用两种不同的暴露测量方法-三氯生的存在与不存在或四分位数-我们评估了三氯生与BMI之间的关联。我们还筛选了所有NHANES血清和尿液生物标志物，以确定可能混淆观察到的相关性的相关因素。与检测不到的三氯生相比，检测到的三氯生水平与BMI增加0.9分相关（p<0.001）。在四分位数分析中，与最低四分位数相比，尿三氯生的第2、第3和第4四分位数分别与BMI增加1.5（p<0.001）、1.0（p = 0.002）和0.3（p = 0.33）相关。 在NHANES中确定的三氯生的一个强相关性是其代谢产物2，4-二氯苯酚（ρ = 0.4）;然而，其与BMI的相关性弱于三氯生。 未发现其他可能的混杂因素。三氯生暴露与BMI增加相关。中等浓度的效应强于高浓度，表明作用机制复杂。
Triclosan—a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies—has the potential to alter both gut microbiota and endocrine function and thereby affect body weight. We investigated the relationship between triclosan and body mass index (BMI) using National Health and Nutrition Examination Surveys (NHANES) from 2003–2008. BMI and spot urinary triclosan levels were obtained from adults. Using two different exposure measures—either presence vs. absence or quartiles of triclosan—we assessed the association between triclosan and BMI. We also screened all NHANES serum and urine biomarkers to identify correlated factors that might confound observed associations. Compared with undetectable triclosan, a detectable level was associated with a 0.9-point increase in BMI (p<0.001). In analysis by quartile, compared to the lowest quartile, the 2nd, 3rd and 4th quartiles of urinary triclosan were associated with BMI increases of 1.5 (p<0.001), 1.0 (p = 0.002), and 0.3 (p = 0.33) respectively. The one strong correlate of triclosan identified in NHANES was its metabolite, 2,4-dichlorophenol (ρ = 0.4); its association with BMI, however, was weaker than that of triclosan. No other likely confounder was identified. Triclosan exposure is associated with increased BMI. Stronger effect at moderate than high levels suggests a complex mechanism of action.
登录
查看更多内容
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
8.8
作者：
Christen, Verena;Crettaz, Pierre;Fent, Karl
通讯作者：
Fent, Karl
影响因子：
4.3
作者：
Crofton, Kevin M.;Paul, Katie B.;Hedge, Joan M.
通讯作者：
Hedge, Joan M.
影响因子：
11.4
作者：
Kolpin, DW;Furlong, ET;Buxton, HT
通讯作者：
Buxton, HT
影响因子：
6
作者：
Jarvis, Martin J.;Fidler, Jennifer;West, Robert
通讯作者：
West, Robert