Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study.
Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study.
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DOI：
10.1186/s12916-020-01846-w
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发表时间：
2020-12-07
期刊：
影响因子：
9.3
通讯作者：
Calderón-Larrañaga A
中科院分区：
文献类型：
--
作者：
Sindi S;Pérez LM;Vetrano DL;Triolo F;Kåreholt I;Sjöberg L;Darin-Mattsson A;Kivipelto M;Inzitari M;Calderón-Larrañaga A
睡眠障碍在老年人中普遍存在，并与各种个体疾病有关。这项研究的目的是调查睡眠障碍是否与老年人多Morphoid发展的速度有关。数据收集自瑞典国家Kungsholmen衰老与护理研究（SNAC-K），这是一项针对60岁以上受试者（N = 3363）的持续人群研究。该研究包括在基线处没有多发病（< 2种慢性疾病）的子样本（n = 1189）。基线睡眠障碍来自综合精神病评定量表，并分为无、轻度和中度-重度。整个9年随访期间的慢性疾病数量来自临床检查。使用线性混合模型研究睡眠障碍与慢性疾病积累速度之间的关系，调整性别，年龄，教育，体力活动，吸烟，饮酒，抑郁，疼痛和精神药物使用。我们重复分析，仅包括心血管、神经精神或肌肉骨骼疾病作为结局。无论潜在的混杂因素如何，中重度睡眠障碍与慢性疾病积累的速度更快相关（平均/年= 0.142，p = 0.008）。中度至重度睡眠障碍与神经精神疾病（RR/年= 0.041，p = 0.016）和肌肉骨骼疾病（RR/年= 0.038，p = 0.025）的累积之间也存在显著正相关，但与心血管疾病无关。当基线痴呆、认知障碍或抑郁的参与者被排除在外时，结果保持稳定。睡眠障碍与更快的慢性疾病积累有关的发现指出了早期发现和治疗睡眠障碍的重要性，这是减少老年人慢性多发病的一种可能策略。在线版本包含补充材料，可通过10.1186/s12916-020-01846-w获得。
Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate–severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Moderate–severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate–severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults. The online version contains supplementary material available at 10.1186/s12916-020-01846-w.
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老年人睡眠：规范性变化，睡眠障碍和治疗选择。
影响因子：
3.3
作者：
Gooneratne NS;Vitiello MV
通讯作者：
Vitiello MV
在九个国家 /地区的50岁或超过50岁的成年人中的慢性病和睡眠问题：一项多国研究。
影响因子：
3.7
作者：
Koyanagi A;Garin N;Olaya B;Ayuso-Mateos JL;Chatterji S;Leonardi M;Koskinen S;Tobiasz-Adamczyk B;Haro JM
通讯作者：
Haro JM
影响因子：
6.6
作者：
Gallo J;Raska M;Kriegova E;Goodman SB
通讯作者：
Goodman SB
影响因子：
5.6
作者：
Burford NG;Webster NA;Cruz-Topete D
通讯作者：
Cruz-Topete D
影响因子：
5
作者：
Dekhtyar, Serhiy;Vetrano, Davide Liborio;Calderon-Larranaga, Amaia
通讯作者：
Calderon-Larranaga, Amaia