Inflammation and its resolution and the musculoskeletal system.
Inflammation and its resolution and the musculoskeletal system.
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DOI:
10.1016/j.jot.2017.05.007
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发表时间:
2017-07
影响因子:
6.6
通讯作者:
Goodman SB
中科院分区:
文献类型:
--
作者:
Gallo J;Raska M;Kriegova E;Goodman SB
Inflammation, an essential tissue response to extrinsic/intrinsic damage, is a very dynamic process in terms of complexity and extension of cellular and metabolic involvement. The aim of the inflammatory response is to eliminate the pathogenic initiator with limited collateral damage of the inflamed tissue, followed by a complex tissue repair to the preinflammation phenotype. Persistent inflammation is a major contributor to the pathogenesis of many musculoskeletal diseases including ageing-related pathologies such as osteoporosis, osteoarthritis, and sarcopaenia. The translational potential of this article: Understanding the mechanisms of inflammation and its resolution is therefore critical for the development of effective regenerative, and therapeutic strategies in orthopaedics.
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