Integrative Transcriptomic, Lipidomic, and Metabolomic Analysis Reveals Potential Biomarkers of Basal and Luminal Muscle Invasive Bladder Cancer Subtypes.
Integrative Transcriptomic, Lipidomic, and Metabolomic Analysis Reveals Potential Biomarkers of Basal and Luminal Muscle Invasive Bladder Cancer Subtypes.
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综合转录组学、脂质组学和代谢组学分析揭示基底肌和腔肌浸润性膀胱癌亚型的潜在生物标志物
DOI：
10.3389/fgene.2021.695662
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发表时间：
2021
影响因子：
3.7
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Feng C;Pan L;Tang S;He L;Wang X;Tao Y;Xie Y;Lai Z;Tang Z;Wang Q;Li T
Muscle invasive bladder cancer (MIBC) is a heterogeneous disease with a high recurrence rate and poor clinical outcomes. Molecular subtype provides a new framework for the study of MIBC heterogeneity. Clinically, MIBC can be classified as basal and luminal subtypes; they display different clinical and pathological characteristics, but the molecular mechanism is still unclear. Lipidomic and metabolomic molecules have recently been considered to play an important role in the genesis and development of tumors, especially as potential biomarkers. Their different expression profiles in basal and luminal subtypes provide clues for the molecular mechanism of basal and luminal subtypes and the discovery of new biomarkers. Herein, we stratified MIBC patients into basal and luminal subtypes using a MIBC classifier based on transcriptome expression profiles. We qualitatively and quantitatively analyzed the lipids and metabolites of basal and luminal MIBC subtypes and identified their differential lipid and metabolite profiles. Our results suggest that free fatty acids (FFAs) and sulfatides (SLs), which are closely associated with immune and stromal cell types, can contribute to the diagnosis of basal and luminal subtypes of MIBC. Moreover, we showed that glycerophosphocholine (GCP)/imidazoles and nucleosides/imidazoles ratios can accurately distinguish the basal and luminal tumors. Overall, by integrating transcriptomic, lipidomic, and metabolomic data, our study reveals specific biomarkers to differentially diagnose basal and luminal MIBC subtypes and may provide a basis for precision therapy of MIBC.
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秀丽隐杆线虫幼虫膜磷脂中多不饱和脂肪酸的隔离会减弱类二十烷酸的生物合成，从而延长存活时间
影响因子：
11.4
作者：
Lam SM;Wang Z;Li J;Huang X;Shui G
通讯作者：
Shui G
影响因子：
2
作者：
Fong MHY;Feng M;McConkey DJ;Choi W
通讯作者：
Choi W
影响因子：
158.5
作者：
Grossman, HB;Natale, RB;Crawford, ED
通讯作者：
Crawford, ED
影响因子：
--
作者：
Lee MY;Yeon A;Shahid M;Cho E;Sairam V;Figlin R;Kim KH;Kim J
通讯作者：
Kim J
影响因子：
5.5
作者：
Dolinar, Klemen;Jan, Vid;Pirkmajer, Sergej
通讯作者：
Pirkmajer, Sergej