Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.
Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.
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DOI：
10.1093/ckj/sfaa221
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发表时间：
2021-08
影响因子：
4.6
通讯作者：
Selby NM
中科院分区：
文献类型：
--
作者：
Buchanan C;Mahmoud H;Cox E;Noble R;Prestwich B;Kasmi I;Taal MW;Francis S;Selby NM
急性肾损伤（AKI）与死亡率的显著增加以及随后的慢性肾脏疾病（CKD）和终末期肾脏疾病相关。我们进行了多参数磁共振成像（MRI），目的是识别AKI和恢复期间肾脏病理生理的潜在非侵入性MRI标志物。9名参与者在AKI发生时接受了住院MRI扫描；7人在AKI后3个月和1年随访扫描。多参数肾脏MRI评估肾脏总容积（TKV）、肾灌注，采用动脉自旋标记、T1制图和血氧水平依赖（BOLD） R2*制图。所有参与者的血清肌酐浓度在aki后1年恢复到基线水平。在AKI时，与健康志愿者和CKD患者的预期范围相比，参与者的TKV增加，皮质/髓质T1增加，皮质灌注减少。在AKI后，TKV和T1值随着时间的推移而下降，并在大多数但不是所有患者中在1年后恢复到预期值。在aki后1年，大多数患者的皮质灌注改善程度较小，仍低于预期范围。BOLD R2*数据显示，随着aki后时间的推移，其增加趋势不显著。我们观察到AKI期间TKV和T1显著增加，皮质灌注显著减少。尽管aki后1年生化恢复，但MRI测量显示一些患者持续异常。我们认为，这些患者可能更有可能发生进一步的AKI发作或进展为CKD，需要进一步的纵向研究来对此进行调查。
Acute kidney injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end-stage kidney disease. We performed multiparametric magnetic resonance imaging (MRI) with the aim of identifying potential non-invasive MRI markers of renal pathophysiology in AKI and during recovery. Nine participants underwent inpatient MRI scans at time of AKI; seven had follow-up scans at 3 months and 1 year following AKI. Multiparametric renal MRI assessed total kidney volume (TKV), renal perfusion using arterial spin labelling, T1 mapping and blood oxygen level-dependent (BOLD) R2* mapping. Serum creatinine concentration had recovered to baseline levels at 1-year post-AKI in all participants. At the time of AKI, participants had increased TKV, increased cortex/medulla T1 and reduced cortical perfusion compared with the expected ranges in healthy volunteers and people with CKD. TKV and T1 values decreased over time after AKI and returned to expected values in most but not all patients by 1 year. Cortical perfusion improved to a lesser extent and remained below the expected range in the majority of patients by 1-year post-AKI. BOLD R2* data showed a non-significant trend to increase over time post-AKI. We observed a substantial increase in TKV and T1 during AKI and a marked decrease in cortical perfusion. Despite biochemical recovery at 1-year post-AKI, MRI measures indicated persisting abnormalities in some patients. We propose that such patients may be more likely to have further AKI episodes or progress to CKD and further longitudinal studies are required to investigate this.
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影响因子：
6.1
作者：
Berchtold, Lena;Friedli, Iris;de Seigneux, Sophie
通讯作者：
de Seigneux, Sophie
影响因子：
3.3
作者：
Gardener, Alexander G.;Francis, Susan T.
通讯作者：
Francis, Susan T.
DOI：
10.2215/cjn.04840513
发表时间：
2014-02-07
影响因子：
9.8
作者：
Faubel, Sarah;Patel, Nayana U.;Cadnapaphornchai, Melissa A.
通讯作者：
Cadnapaphornchai, Melissa A.
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
DOI：
10.1093/ndt/gfy243
发表时间：
2018-09-01
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Pruijm M;Mendichovszky IA;Liss P;Van der Niepen P;Textor SC;Lerman LO;Krediet CTP;Caroli A;Burnier M;Prasad PV
通讯作者：
Prasad PV