Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.
Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.
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DOI：
10.1093/ndt/gfy243
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发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Prasad PV
中科院分区：
文献类型：
--
作者：
Pruijm M;Mendichovszky IA;Liss P;Van der Niepen P;Textor SC;Lerman LO;Krediet CTP;Caroli A;Burnier M;Prasad PV
组织缺氧在许多肾脏疾病的发生和进展中起着关键作用。血氧水平依赖性磁共振成像（BOLD-MRI）是监测人体肾组织氧合最有前途的成像技术。 BOLD-MRI 逐个体素测量肾组织脱氧血红蛋白水平。结果测量 R2*（以每秒表示的横向弛豫率）的增加对应于较高的脱氧血红蛋白浓度，表明氧合较低，而 R2* 的减少则表明氧合较高。 BOLD-MRI 已针对动物微穿刺技术进行了验证。只要生理和技术条件标准化，其再现性已在人类身上得到证实。 BOLD-MRI 显示，患有慢性肾病 (CKD) 或肾动脉严重狭窄的患者的组织氧合水平低于对照组。此外，皮质氧合最低的 CKD 患者的肾脏结局最差。最后，BOLD-MRI已被用于评估药物对肾组织氧合的影响，并可能提供早期识别具有肾保护或肾毒性作用的药物的可能性。不幸的是，使用不同的方法来准备患者、采集 MRI 数据和分析 BOLD 图像。欧洲科技合作 (COST) 行动“慢性肾脏病磁共振成像生物标志物”(PARENCHIMA) 等国际努力旨在协调这一过程，以促进在不久的将来将该技术引入临床实践。本文对该领域进行的研究进行了广泛的概述，总结了该技术的优点和缺点，提供了有关患者准备、图像采集和分析的建议，并提出了临床应用和未来发展的建议。
Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action ‘Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease’ (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.
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影响因子：
64.8
作者：
AUKLAND, K;KROG, J
通讯作者：
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