Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis.
Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis.
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DOI：
10.1136/bmj.d4488
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发表时间：
2011-08-26
期刊：
影响因子：
--
通讯作者：
Franco OH
中科院分区：
文献类型：
--
作者：
Buitrago-Lopez A;Sanderson J;Johnson L;Warnakula S;Wood A;Di Angelantonio E;Franco OH
目的评价巧克力摄入量与心血管代谢紊乱风险的关系。设计随机对照试验和观察性研究的系统回顾和荟萃分析。数据来源Medline、Embase、科克伦图书馆、PubMed、CINAHL、IPA、Web of Science、Scopus、Pascal、相关研究参考文献列表（截至2010年10月）以及与作者的电子邮件联系。研究选择在成人中进行的随机试验和队列，病例对照和横断面研究，其中报告了巧克力消费与心脏代谢疾病相关结局风险之间的关联。数据提取由两名独立的研究人员提取数据，并在第三名研究人员的参与下达成共识。主要结局为心血管代谢疾病，包括心血管疾病（冠心病和卒中）、糖尿病和代谢综合征。一项荟萃分析通过比较最高和最低巧克力摄入量来评估心脏代谢紊乱的风险。结果从4576篇文献中筛选出7篇符合纳入标准的文献，共纳入114009例受试者。这些研究都不是随机试验，6项是队列研究，1项是横断面研究。在这七项研究中，巧克力消费量的测量、方法和结果的评估存在很大差异。七项研究中的五项报告了较高水平的巧克力消费与心脏代谢疾病风险之间的有益联系。与最低水平相比，最高水平的巧克力消费与心血管疾病减少37%（相对风险0.63（95%置信区间0.44至0.90））和中风减少29%相关。结论根据观察证据，巧克力摄入量似乎与心脏代谢疾病风险的大幅降低有关。需要进一步的实验研究来证实巧克力消费的潜在有益效果。
Objective To evaluate the association of chocolate consumption with the risk of developing cardiometabolic disorders. Design Systematic review and meta-analysis of randomised controlled trials and observational studies. Data sources Medline, Embase, Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, reference lists of relevant studies to October 2010, and email contact with authors. Study selection Randomised trials and cohort, case-control, and cross sectional studies carried out in human adults, in which the association between chocolate consumption and the risk of outcomes related to cardiometabolic disorders were reported. Data extraction Data were extracted by two independent investigators, and a consensus was reached with the involvement of a third. The primary outcome was cardiometabolic disorders, including cardiovascular disease (coronary heart disease and stroke), diabetes, and metabolic syndrome. A meta-analysis assessed the risk of developing cardiometabolic disorders by comparing the highest and lowest level of chocolate consumption. Results From 4576 references seven studies met the inclusion criteria (including 114 009 participants). None of the studies was a randomised trial, six were cohort studies, and one a cross sectional study. Large variation was observed between these seven studies for measurement of chocolate consumption, methods, and outcomes evaluated. Five of the seven studies reported a beneficial association between higher levels of chocolate consumption and the risk of cardiometabolic disorders. The highest levels of chocolate consumption were associated with a 37% reduction in cardiovascular disease (relative risk 0.63 (95% confidence interval 0.44 to 0.90)) and a 29% reduction in stroke compared with the lowest levels. Conclusions Based on observational evidence, levels of chocolate consumption seem to be associated with a substantial reduction in the risk of cardiometabolic disorders. Further experimental studies are required to confirm a potentially beneficial effect of chocolate consumption.
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影响因子：
8.3
作者：
Grassi, D;Necozione, S;Ferri, C
通讯作者：
Ferri, C
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4.5
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作者：
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通讯作者：
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影响因子：
24
作者：
Heiss, Christian;Jahn, Sarah;Yeghiazarians, Yerem
通讯作者：
Yeghiazarians, Yerem