Invigoration of reward seeking by cue and proximity encoding in the nucleus accumbens.
Invigoration of reward seeking by cue and proximity encoding in the nucleus accumbens.
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DOI：
10.1016/j.neuron.2013.04.010
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发表时间：
2013-06-05
期刊：
影响因子：
16.2
通讯作者：
Nicola SM
中科院分区：
文献类型：
--
作者：
McGinty VB;Lardeux S;Taha SA;Kim JJ;Nicola SM
A key function of the nucleus accumbens is to promote vigorous reward-seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here we study cued flexible approach behavior, a form of reward-seeking that strongly depends on the accumbens, and we describe a robust, single-cell neural correlate of behavioral vigor in the excitatory response of accumbens neurons to reward-predictive cues. Well before locomotion begins, this cue-evoked excitation predicts both the movement initiation latency and speed of subsequent flexible approach responses, but not of stereotyped, inflexible responses. Moreover, the excitation simultaneously signals the subject’s proximity to the approach target, a signal that appears to mediate greater response vigor on trials that begin with the subject closer to the target. These results demonstrate a neural mechanism for response invigoration whereby accumbens neuronal encoding of reward availability and target proximity together drive the onset and speed of reward-seeking locomotion.
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DOI：
10.1523/jneurosci.3958-10.2010
发表时间：
2010-12-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Nicola SM
通讯作者：
Nicola SM
DOI：
10.1523/jneurosci.6491-10.2011
发表时间：
2011-05-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ambroggi F;Ghazizadeh A;Nicola SM;Fields HL
通讯作者：
Fields HL
DOI：
10.1523/jneurosci.0593-12.2012
发表时间：
2012-09-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lansink CS;Jackson JC;Lankelma JV;Ito R;Robbins TW;Everitt BJ;Pennartz CM
通讯作者：
Pennartz CM
影响因子：
3
作者：
Drai, D;Benjamini, Y;Golani, I
通讯作者：
Golani, I
影响因子：
2.9
作者：
LAVOIE, AM;MIZUMORI, SJY
通讯作者：
MIZUMORI, SJY