The Janus-like role of proline metabolism in cancer.
The Janus-like role of proline metabolism in cancer.
复制标题
脯氨酸代谢在癌症中的作用。
DOI：
10.1038/s41420-020-00341-8
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发表时间：
2020
影响因子：
7
通讯作者：
Rufini A
中科院分区：
文献类型：
--
作者：
Burke L;Guterman I;Palacios Gallego R;Britton RG;Burschowsky D;Tufarelli C;Rufini A
非必需氨基酸L-脯氨酸的代谢正在成为维持癌细胞增殖、存活和转移扩散的代谢重新布线中的关键途径。吡咯啉-5-羧酸还原酶（PYCR）和脯氨酸脱氢酶（PRODH）分别催化脯氨酸生物合成的最后一步和其催化的第一步，已经广泛地与几种恶性肿瘤的进展相关，并且已经暴露为抗癌药物开发的潜在靶标。随着对脯氨酸代谢和癌症之间联系的研究的积累，这种相互作用的复杂性，有时是矛盾的性质出现了。很明显，脯氨酸代谢酶在癌症中的作用取决于肿瘤类型，不同的癌症和癌症相关表型对这些酶表现出不同的依赖性。出乎意料的是，重新布线脯氨酸代谢的结果也不同的营养和氧气限制的条件。在这里，我们提供了一个全面的审查脯氨酸代谢在癌症中，我们整理的实验证据，脯氨酸代谢与癌症进展的不同方面，并严格讨论所涉及的潜在机制。
The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for anticancer drug development. As investigations into the links between proline metabolism and cancer accumulate, the complexity, and sometimes contradictory nature of this interaction emerge. It is clear that the role of proline metabolism enzymes in cancer depends on tumor type, with different cancers and cancer-related phenotypes displaying different dependencies on these enzymes. Unexpectedly, the outcome of rewiring proline metabolism also differs between conditions of nutrient and oxygen limitation. Here, we provide a comprehensive review of proline metabolism in cancer; we collate the experimental evidence that links proline metabolism with the different aspects of cancer progression and critically discuss the potential mechanisms involved.
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影响因子：
5.9
作者：
Comes, Stefania;Gagliardi, Miriam;Laprano, Nicola;Fico, Annalisa;Cimmino, Amelia;Palamidessi, Andrea;De Cesare, Dario;De Falco, Sandro;Angelini, Claudia;Scita, Giorgio;Patriarca, Eduardo J.;Matarazzo, Maria R.;Minchiotti, Gabriella
通讯作者：
Minchiotti, Gabriella
DOI：
10.1111/febs.14195
发表时间：
2017-10
期刊：
The FEBS journal
影响因子：
--
作者：
Burridge K
通讯作者：
Burridge K
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7.4
作者：
BOGGESS, SF;KOEPPE, DE;STEWART, CR
通讯作者：
STEWART, CR
影响因子：
9
作者：
通讯作者：
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