Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner.
Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner.
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肥胖和 2 型糖尿病受试者的最大收缩后血容量反应以肌肉特异性方式减弱。
DOI：
10.1152/ajpheart.00060.2011
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Damon,BruceM
中科院分区：
文献类型：
--
作者：
Sanchez,OttoA;Copenhaver,ElizabethA;Chance,MartiA;Fowler,MichaelJ;Towse,TheodoreF;Kent-Braun,JaneA;Damon,BruceM
本研究的目的是确定使用MRI检测的2型糖尿病（T2DM）、肥胖和消瘦个体之间的测量后收缩血容量和氧合反应是否存在差异。8例T2DM患者按年龄、性别和人种分别与体重指数（肥胖）和瘦型受试者相似的非T2DM个体相匹配。使用双梯度回波、回波平面成像序列进行功能性MRI，重复时间为1 s，两个回波时间（TE = 6和46 ms）。在50%和100%的最大随意收缩（MVC）力下进行10秒等长背屈收缩之前、期间和之后采集数据。将胫骨前肌和趾长伸肌的MRI信号强度（SI）变化绘制为每个TE的时间函数。从每个时间过程中，确定TE = 6 ms（Δ SI 6）和TE = 46 ms（Δ SI 46）的最小和最大收缩后SI（ΔSI）之间的差异，分别反映血容量和氧合血红蛋白饱和度的变化。在50%MVC收缩后，三组的平均收缩后Δ SI6值相似。仅在MVC和仅在EDL肌肉中，T2DM和肥胖参与者的Δ SI 6比瘦个体低0.56%。同样，仅在MVC后，T2DM受试者的EDL中的Δ SI46反应低于瘦个体。这些数据表明，骨骼肌小血管损伤发生在T2DM和体重指数匹配的受试者中，具有肌肉特异性和收缩强度依赖性。
The purpose of this study was to determine whether there are differences in postisometric contraction blood volume and oxygenation responses among groups of type 2 diabetes mellitus (T2DM), obese, and lean individuals detectable using MRI. Eight T2DM patients were individually matched by age, sex, and race to non-T2DM individuals with similar body mass index (obese) and lean subjects. Functional MRI was performed using a dual-gradient-recalled echo, echo-planar imaging sequence with a repetition time of 1 s and at two echo times (TE = 6 and 46 ms). Data were acquired before, during, and after 10-s isometric dorsiflexion contractions performed at 50 and 100% of maximal voluntary contraction (MVC) force. MRI signal intensity (SI) changes from the tibialis anterior and extensor digitorum longus muscles were plotted as functions of time for each TE. From each time course, the difference between the minimum and the maximum postcontraction SI (ΔSI) were determined for TE = 6 ms (ΔSI6) and TE = 46 ms (ΔSI46), reflecting variations in blood volume and oxyhemoglobin saturation, respectively. Following 50% MVC contractions, the mean postcontraction ΔSI6values were similar in the three groups. Following MVC only, and in the EDL muscle only, T2DM and obese participants had ∼56% lower ΔSI6than the lean individuals. Also following MVC only, the ΔSI46response in the EDL was lower in T2DM subjects than in lean individuals. These data suggest that skeletal muscle small vessel impairment occurs in T2DM and body mass index-matched subjects, in muscle-specific and contraction intensity-dependent manners.
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己糖端基异构体的胰岛辨别。
影响因子：
--
作者：
M. J. Achs;D. Garfinkel
通讯作者：
D. Garfinkel
向灌注液中添加葡萄糖后大鼠心脏代谢的计算机模拟。
影响因子：
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作者：
M. J. Achs;D. Garfinkel
通讯作者：
D. Garfinkel
朗格汉斯岛葡萄糖激酶的色谱分离度和动力学表征。
DOI：
10.1073/pnas.80.1.85
发表时间：
1983
影响因子：
11.1
作者：
Meglasson,MD;Burch,PT;Berner,DK;Najafi,H;Vogin,AP;Matschinsky,FM
通讯作者：
Matschinsky,FM
在酶的生理浓度下调节肌肉磷酸果糖激酶。
影响因子：
4.8
作者：
L. Boscá;J. J. Aragón;A. Sols
通讯作者：
A. Sols
DOI：
10.1152/ajpendo.1988.255.2.e201
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Achs,MJ;Garfinkel,D
通讯作者：
Garfinkel,D