X-Linked Signature of Reproductive Isolation in Humans is Mirrored in a Howler Monkey Hybrid Zone.
X-Linked Signature of Reproductive Isolation in Humans is Mirrored in a Howler Monkey Hybrid Zone.
复制标题
人类生殖隔离的X连锁特征在吼猴杂交区中是镜像的。
DOI：
10.1093/jhered/esaa021
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发表时间：
2020-09-30
期刊：
影响因子：
--
通讯作者：
Cortés-Ortiz L
中科院分区：
文献类型：
--
作者：
Baiz MD;Tucker PK;Mueller JL;Cortés-Ortiz L
生殖隔离是物种形成的基本步骤。虽然性染色体在许多模型系统中与生殖隔离有关，包括原始人，但性染色体基因座对自然种群物种形成的贡献的遗传研究相对较少。自然杂交区可以帮助识别基因组区域生殖隔离，如杂交不亲和位点，因为这些区域表现出减少的亲物种之间的渐渗。在这里，我们使用灵长类杂交区（Alouatta palliata × Alouatta pigra）来测试与常染色体SNP相比X连锁SNP的渐渗减少。鉴定A. palliata，我们使用了性别偏见的映射方法与全基因组重测序数据。然后，我们使用基因组无性系分析与减少代表性的序列数据的父母A。palliata和A. pigra个体和杂种（n = 88）以鉴定具有非中性基因渗入的区域。我们在A. palliata，其中大部分共线映射到绒猴和人类X染色体。我们发现，X连锁的SNP减少了基因渗入和来自A.与常染色体SNP相比，palliata。一个基因渗入减少的异常区域与先前描述的人类X染色体上古人类祖先的“沙漠”重叠。这些结果与X染色体在动物类群物种形成中的重要作用一致，并进一步表明灵长类动物生殖隔离进化的基因组基础中的共同特征。
Reproductive isolation is a fundamental step in speciation. While sex chromosomes have been linked to reproductive isolation in many model systems, including hominids, genetic studies of the contribution of sex chromosome loci to speciation for natural populations are relatively sparse. Natural hybrid zones can help identify genomic regions contributing to reproductive isolation, like hybrid incompatibility loci, since these regions exhibit reduced introgression between parental species. Here, we use a primate hybrid zone (Alouatta palliata × Alouatta pigra) to test for reduced introgression of X-linked SNPs compared to autosomal SNPs. To identify X-linked sequence in A. palliata, we used a sex-biased mapping approach with whole-genome re-sequencing data. We then used genomic cline analysis with reduced-representation sequence data for parental A. palliata and A. pigra individuals and hybrids (n = 88) to identify regions with non-neutral introgression. We identified ~26 Mb of non-repetitive, putatively X-linked genomic sequence in A. palliata, most of which mapped collinearly to the marmoset and human X chromosomes. We found that X-linked SNPs had reduced introgression and an excess of ancestry from A. palliata as compared to autosomal SNPs. One outlier region with reduced introgression overlaps a previously described “desert” of archaic hominin ancestry on the human X chromosome. These results are consistent with a large role for the X chromosome in speciation across animal taxa and further, suggest shared features in the genomic basis of the evolution of reproductive isolation in primates.
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影响因子：
2.5
作者：
Cortes-Ortiz, Liliana;Nidiffer, Marcella D.;Canales-Espinosa, Domingo
通讯作者：
Canales-Espinosa, Domingo
DOI：
10.1093/bioinformatics/btx346
发表时间：
2017-10-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Gel B;Serra E
通讯作者：
Serra E
有效鉴定人和果蝇基因组中的Y染色体序列。
影响因子：
7
作者：
Carvalho AB;Clark AG
通讯作者：
Clark AG
DOI：
10.1126/science.aag2602
发表时间：
2016-10-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
de Manuel M;Kuhlwilm M;Frandsen P;Sousa VC;Desai T;Prado-Martinez J;Hernandez-Rodriguez J;Dupanloup I;Lao O;Hallast P;Schmidt JM;Heredia-Genestar JM;Benazzo A;Barbujani G;Peter BM;Kuderna LF;Casals F;Angedakin S;Arandjelovic M;Boesch C;Kühl H;Vigilant L;Langergraber K;Novembre J;Gut M;Gut I;Navarro A;Carlsen F;Andrés AM;Siegismund HR;Scally A;Excoffier L;Tyler-Smith C;Castellano S;Xue Y;Hvilsom C;Marques-Bonet T
通讯作者：
Marques-Bonet T
影响因子：
3.3
作者：
Cortes-Ortiz, Liliana;Duda, Thomas F., Jr.;Berminghamt, Eldredge
通讯作者：
Berminghamt, Eldredge