Risk factors for cancer of the oral cavity and oro-pharynx in Cuba.
Risk factors for cancer of the oral cavity and oro-pharynx in Cuba.
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古巴口腔癌和Oo-pharynx癌症的危险因素。
DOI：
10.1054/bjoc.2000.1825
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发表时间：
2001-07-06
影响因子：
8.8
通讯作者：
Franceschi, S
中科院分区：
文献类型：
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作者：
Garrote, LF;Herrero, R;Reyes, RMO;Vaccarella, S;Anta, JL;Ferbeye, L;Muñoz, N;Franceschi, S
在世界范围内，古巴的口腔癌和口咽癌发病率居中。我们研究了200例口腔和咽癌患者，其中57名女性（中位年龄= 64岁）和200名医院对照组，频率与年龄和性别的病例相匹配，与吸烟和饮酒史、25种食物或食物组的摄入量、口腔卫生和性活动指标以及性传播疾病史有关。优势比（OR）和95%置信区间（CI）通过无条件多元Logistic回归获得，并根据年龄、性别、居住地区、教育程度、吸烟和饮酒习惯进行调整。在多变量模型中，高教育水平和白领职业，而不是白色种族，与口腔癌风险减半有关。每天吸烟≥30支显示OR为20.8（95% CI：8.9-48.3），与每天吸烟≥4支雪茄（OR = 20.5）相似。每周饮酒≥ 70次的OR为5.7（95%CI：1.8-18.5）。烈酒是迄今为止最大的酒精来源。风险增加与玉米（OR = 1.9），肉类（OR = 2.2）和火腿和意大利腊肠（OR = 2.0）的最高三分位摄入量相关，而高水果摄入量与风险显著降低（OR = 0.4）相关。在牙齿护理指标中，口腔检查时缺牙数和一般口腔状况差的OR分别为2.7和2.6。性伴侣的数量、婚姻或与妓女的接触、口交的做法和各种性传播疾病的历史，包括生殖器疣，与口腔癌的风险无关。在古巴，82%的口腔癌病例可归因于吸烟，19%仅归因于吸烟。归因于饮酒（7%）和水果摄入量低（11%）的比例更为温和。因此，减少吸烟和雪茄是目前古巴预防口腔癌的关键。© 2001年癌症研究运动http://www.bjcancer.com
In terms of worldwide levels, Cuba has an intermediate incidence of cancer of the oral cavity and oro-pharynx. We studied 200 cases of cancer of the oral cavity and pharynx, of whom 57 women (median age = 64) and 200 hospital controls, frequency matched with cases by age and sex, in relation to smoking and drinking history, intake of 25 foods or food groups, indicators of oral hygiene and sexual activity, and history of sexually transmitted diseases. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from unconditional multiple logistic regressions and adjusted for age, sex, area of residence, education, and smoking and drinking habits. In the multivariate model, high educational level and white-collar occupation, but not white race, were associated with halving of oral cancer risk. Smoking ≥30 cigarettes per day showed an OR of 20.8 (95% CI: 8.9–48.3), similar to smoking ≥4 cigars daily (OR = 20.5). Drinking ≥ 70 alcoholic drinks per week showed an OR of 5.7 (95% CI: 1.8–18.5). Hard liquors were by far the largest source of alcohol. Increased risk was associated with the highest tertile of intake for maize (OR = 1.9), meat (OR = 2.2) and ham and salami (OR = 2.0), whereas high fruit intake was associated with significantly decreased risk (OR = 0.4). Among indicators of dental care, number of missing teeth and poor general oral condition at oral inspection showed ORs of 2.7 and 2.6, respectively. Number of sexual partners, marriages or contacts with prostitutes, practice of oral sex and history of various sexually transmitted diseases, including genital warts, were not associated with oral cancer risk. 82% of oral cancer cases in Cuba were attributable to tobacco smoking, 19% to smoking cigars or pipe only. The fractions attributable to alcohol drinking (7%) and low fruit intake (11%) were more modest. Thus, decreases in cigarette and cigar smoking are at present the key to oral cancer prevention in Cuba. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
4.8
作者：
De Stefani, E;Deneo-Pellegrini, H;Ronco, A
通讯作者：
Ronco, A
影响因子：
2.3
作者：
Hayes, RB;Bravo-Otero, E;Winn, DM
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Winn, DM
影响因子：
10.3
作者：
DAY, GL;BLOT, WJ;FRAUMENI, JF
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FRAUMENI, JF
影响因子：
4.8
作者：
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通讯作者：
Muñoz, N
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作者：
Gronbæk, M;Becker, U;Sorensen, TIA
通讯作者：
Sorensen, TIA