Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging.
Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging.
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DOI：
10.1016/j.jalz.2008.08.006
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发表时间：
2008-11
影响因子：
14
通讯作者：
Trojanowski, John Q.
中科院分区：
文献类型：
--
作者：
Bain, Lisa J.;Jedrziewski, Kathy;Morrison-Bogorad, Marcelle;Albert, Marilyn;Cotman, Carl;Hendrie, Hugh;Trojanowski, John Q.
据宾夕法尼亚大学老龄化研究所所长约翰·特罗扬诺夫斯基博士介绍，自2006年1月以来，美国每7秒就有一个婴儿潮一代年满60岁，他介绍了这次公众研讨会的主题“健康的布莱恩老龄化”。随着这些婴儿潮一代年龄的增长，他们越来越关注健康的老龄化，特别是健康的大脑老龄化，并寻求避免与衰老相关的神经退行性疾病，如轻度认知障碍（MCI），阿尔茨海默病（AD）以及其他与进行性脑退化和认知功能持续下降相关的衰老相关神经退行性疾病。世界人口正在经历一场长寿革命，其中65岁以上人口在全球人口中增长最快。根据不同的方法和途径，对美国AD患病率有一系列估计，从240万1到522万。但尽管如此，随着人口老龄化，AD患者的数量预计将在未来几年爆炸，除非找到预防或治疗该疾病的方法。事实上，在美国大约每70秒就有人患上AD，AD最近已取代糖尿病成为美国第6大死亡原因。据估计，到2030年，美国可能有多达770万人患有这种疾病，到2050年，这一数字可能上升到1100万至1600万人。据估计，美国每年的AD成本超过1000亿美元，AD也可能影响其他国家的经济，包括发展中国家。例如，总部位于伦敦的阿尔茨海默病国际组织已经确定，
Since January of 2006, a baby boomer has turned 60 every seven seconds in the United States, according to Dr. John Trojanowski, director of the Institute on Aging at University of Pennsylvania, who introduced the theme of this public symposium on “Healthy Brian Aging”. And as these baby boomers get older, they are increasingly concerned about healthy aging, particularly healthy brain aging, and seek to avoid aging-related neurodegenerative disorders, like mild cognitive impairment (MCI), Alzheimer’s disease (AD) and other aging related neurodegenerative disorders associated with progressive brain degeneration and relentless declines in cognitive function.AD is of particular concern because its prevalence increases exponentially with age after 65 and the world population is experiencing a longevity revolution in which the most rapidly expanding segment of the global population is that over age 65. There are a range of estimates on prevalence of AD in the United States, from 2.4 million1 to 5.22 million, based on differing methodologies and approaches. But this notwithstanding, the number of people with AD is expected to explode in coming years as the population ages, unless ways to prevent or treat the disease are found. Indeed, someone develops AD in the United States approximately every 70 seconds, and AD has recently displaced diabetes as the 6th leading cause of death in the United States. By 2030, by one estimate, as many as 7.7 million people in the United States could have the disease, and by 2050 this number could rise to between 11 million and 16 million people3. It is currently estimated that the cost of AD in the US exceeds $100 billion annually, and AD will likely affect the economies of other countries, including developing nations, as well. For example, the London-based Alzheimer’s Disease International has determined that
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影响因子：
14
作者：
Jedrziewski, A. Kathryn;Lee, Virginia M. -Y.;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
3.1
作者：
Kramer, AF;Colcombe, SJ;Webb, AG
通讯作者：
Webb, AG
影响因子：
39.2
作者：
Larson, EB;Wang, L;Kukull, W
通讯作者：
Kukull, W
影响因子：
3.7
作者：
Park, DC;Lautenschlager, G;Smith, PK
通讯作者：
Smith, PK
影响因子：
4.2
作者：
Launer, Lenore J.;Petrovitch, Helen;White, Lon R.
通讯作者：
White, Lon R.