Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.

Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.
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DOI:
10.1007/s12035-011-8201-5
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发表时间:
2011-12
影响因子:
5.1
通讯作者:
Suzuki, Takashi
Suzuki, Takashi
中科院分区:
医学2区
文献类型:
--
作者:
Berger-Mueller, Sandra;Suzuki, Takashi

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The Flamingo/Celsr seven-transmembrane cadherins represent a conserved subgroup of the cadherin superfamily involved in multiple aspects of development. In the developing nervous system, Fmi/Celsr control axonal blueprint and dendritic morphogenesis from invertebrates to mammals. As expected from their molecular structure, seven-transmembrane cadherins can induce cell–cell homophilic interactions but also intracellular signaling. Fmi/Celsr is known to regulate planar cell polarity (PCP) through interactions with PCP proteins. In the nervous system, Fmi/Celsr can function in collaboration with or independently of other PCP genes. Here, we focus on recent studies which show that seven-transmembrane cadherins use distinct molecular mechanisms to achieve diverse functions in the development of the nervous system.
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