Modeling cell-in-cell structure into its biological significance.

Modeling cell-in-cell structure into its biological significance.
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DOI:
10.1038/cddis.2013.147
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发表时间:
2013-05-16
影响因子:
9
通讯作者:
Wang, X-n
Wang, X-n
中科院分区:
生物学1区
文献类型:
--
作者:
He, M-f;Wang, S.;Wang, Y.;Wang, X-n

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Although cell-in-cell structure was noted 100 years ago, the molecular mechanisms of ‘entering' and the destination of cell-in-cell remain largely unclear. It takes place among the same type of cells (homotypic cell-in-cell) or different types of cells (heterotypic cell-in-cell). Cell-in-cell formation affects both effector cells and their host cells in multiple aspects, while cell-in-cell death is under more intensive investigation. Given that cell-in-cell has an important role in maintaining homeostasis, aberrant cell-in-cell process contributes to the etiopathology in humans. Indeed, cell-in-cell is observed in many pathological processes of human diseases. In this review, we intend to discuss the biological models of cell-in-cell structures under physiological and pathological status.
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