Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers.
Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers.
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DOI：
10.18632/oncotarget.3402
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发表时间：
2015-04-30
期刊：
影响因子：
--
通讯作者：
Aneja R
中科院分区：
文献类型：
--
作者：
Pannu V;Mittal K;Cantuaria G;Reid MD;Li X;Donthamsetty S;McBride M;Klimov S;Osan R;Gupta MV;Rida PC;Aneja R
Centrosome amplification (CA), a cell-biological trait, characterizes pre-neoplastic and pre-invasive lesions and is associated with tumor aggressiveness. Recent studies suggest that CA leads to malignant transformation and promotes invasion in mammary epithelial cells. Triple negative breast cancer (TNBC), a histologically-aggressive subtype shows high recurrence, metastases, and mortality rates. Since TNBC and non-TNBC follow variable kinetics of metastatic progression, they constitute a novel test bed to explore if severity and nature of CA can distinguish them apart. We quantitatively assessed structural and numerical centrosomal aberrations for each patient sample in a large-cohort of grade-matched TNBC (n = 30) and non-TNBC (n = 98) cases employing multi-color confocal imaging. Our data establish differences in incidence and severity of CA between TNBC and non-TNBC cell lines and clinical specimens. We found strong correlation between CA and aggressiveness markers associated with metastasis in 20 pairs of grade-matched TNBC and non-TNBC specimens (p < 0.02). Time-lapse imaging of MDA-MB-231 cells harboring amplified centrosomes demonstrated enhanced migratory ability. Our study bridges a vital knowledge gap by pinpointing that CA underlies breast cancer aggressiveness. This previously unrecognized organellar inequality at the centrosome level may allow early-risk prediction and explain higher tumor aggressiveness and mortality rates in TNBC patients.
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DOI：
10.1186/bcr76
发表时间：
2000
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.95.6.2950
发表时间：
1998-03-17
影响因子：
11.1
作者：
Lingle, WL;Lutz, WH;Salisbury, JL
通讯作者：
Salisbury, JL
影响因子：
--
作者：
Sato, N;Mizumoto, K;Tanaka, M
通讯作者：
Tanaka, M
伯基特淋巴瘤中没有持续的数值染色体不稳定性，过度的中心体异常。
影响因子：
37.3
作者：
Duensing, Stefan;Lee, Benjamin H;Dal Cin, Paola;Munger, Karl
通讯作者：
Munger, Karl
影响因子：
3.8
作者：
Seong MW;Cho SI;Kim KH;Chung IY;Kang E;Lee JW;Park SK;Lee MH;Choi DH;Yom CK;Noh WC;Chang MC;Park SS;Kim SW;Korean Hereditary Breast Cancer Study Group
通讯作者：
Korean Hereditary Breast Cancer Study Group