Microbiome-Immune Interactions in Allergy and Asthma.
Microbiome-Immune Interactions in Allergy and Asthma.
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DOI：
10.1016/j.jaip.2022.05.038
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发表时间：
2022-09
影响因子：
9.4
通讯作者：
Lynch, Susan, V
中科院分区：
文献类型：
--
作者：
Huang, Yvonne J.;Porsche, Cara;Kozik, Ariangela J.;Lynch, Susan, V
人类微生物群已被确定为宿主健康的关键调节者，这在很大程度上是由于其与宿主免疫的不断相互作用和影响。目前已知，从产前到成年的一系列环境暴露会影响粘膜和真皮组织中微生物组的组成和分子生产力，对宿主免疫功能产生短期和长期影响。在这里，我们回顾了该领域的最新发现，这些发现为微生物-免疫相互作用如何促进和维持与过敏和哮喘相关的免疫功能障碍提供了见解。我们考虑了生命早期微生物组的扰动和与儿童时期过敏和哮喘发展相关的免疫功能障碍的分子基础，以及与老年疾病患者过敏和哮喘表型属性相关的微生物组特征。
The human microbiota has been established as a key regulator of host health, in large part due to its constant interaction with, and impact on, host immunity. A range of environmental exposures, spanning from the prenatal period through adulthood are now known to impact the composition and molecular productivity of microbiomes across mucosal and dermal tissues with short- and long-term consequences for host immune function. Here we review the more recent findings in the field that provide insights into how microbial-immune interactions promote and sustain immune dysfunction associated with allergy and asthma. We consider both early life microbiome perturbation and the molecular underpinnings of immune dysfunction associated with subsequent allergy and asthma development in childhood, as well as microbiome features that relate to phenotypic attributes of allergy and asthma in older patients with established disease.
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影响因子：
16.6
作者：
Durack J;Kimes NE;Lin DL;Rauch M;McKean M;McCauley K;Panzer AR;Mar JS;Cabana MD;Lynch SV
通讯作者：
Lynch SV
DOI：
10.1016/j.jaci.2020.03.028
发表时间：
2020-11
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Durack J;Christian LS;Nariya S;Gonzalez J;Bhakta NR;Ansel KM;Beigelman A;Castro M;Dyer AM;Israel E;Kraft M;Martin RJ;Mauger DT;Peters SP;Rosenberg SR;Sorkness CA;Wechsler ME;Wenzel SE;White SR;Lynch SV;Boushey HA;Huang YJ;National Heart, Lung, and Blood Institute’s ”AsthmaNet“
通讯作者：
National Heart, Lung, and Blood Institute’s ”AsthmaNet“
DOI：
10.1073/pnas.1310750111
发表时间：
2014-01-14
影响因子：
11.1
作者：
Fujimura, Kei E.;Demoor, Tine;Lynch, Susan V.
通讯作者：
Lynch, Susan V.
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
2.6
作者：
Czosnykowska-Lukacka, Matylda;Lis-Kuberka, Jolanta;Orczyk-Pawilowicz, Magdalena
通讯作者：
Orczyk-Pawilowicz, Magdalena