Intravenous immunoglobulin for infectious diseases: back to the pre-antibiotic and passive prophylaxis era?

Intravenous immunoglobulin for infectious diseases: back to the pre-antibiotic and passive prophylaxis era?
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DOI:
10.1016/j.tips.2004.04.002
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发表时间:
2004-06
影响因子:
13.8
通讯作者:
Kaveri SV
Kaveri SV
中科院分区:
医学1区
文献类型:
--
作者:
Bayry J;Lacroix-Desmazes S;Kazatchkine MD;Kaveri SV

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新型传染源数量的急剧增加和对抗菌药物的耐药性激发了对抗传染病的战争中对辅助疗法的需求。令人兴奋的最近的研究已经证明了使用静脉注射免疫球蛋白(IVIg)形式的抗体对抗感染。由于免疫球蛋白具有广谱抗菌和抗病毒特异性,IVIg提供了独立于病原体耐药性的抗微生物功效,并代表了治疗尚未获得特异性治疗的疾病的有希望的替代策略。
The dramatic increase in both the number of novel infectious agents and resistance to antimicrobial drugs has incited the need for adjunct therapies in the war against infectious diseases. Exciting recent studies have demonstrated the use of antibodies in the form of intravenous immunoglobulin (IVIg) against infections. By virtue of the diverse repertoire of immunoglobulins that possess a wide spectrum of antibacterial and antiviral specificities, IVIg provides antimicrobial efficacy independently of pathogen resistance and represents a promising alternative strategy for the treatment of diseases for which a specific therapy is not yet available.
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