Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability.
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability.
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DOI：
10.1016/j.jalz.2015.12.005
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发表时间：
2016-06
影响因子：
14
通讯作者：
Masliah, Eliezer
中科院分区：
文献类型：
--
作者：
de Wilde, Martijn C.;Overk, Cassia R.;Sijben, John W.;Masliah, Eliezer
突触丧失与阿尔茨海默病（AD）中的认知缺陷最相关，其中淀粉样蛋白β的寡聚神经毒性物质似乎有助于突触病理学。虽然已经在有限的样本量下进行了许多临床病理学研究，但没有涵盖大样本的系统性研究。因此，我们进行了荟萃分析研究。我们确定了417篇报道AD患者死后突触和突触标记丢失的文献。使用子选定出版物的单个数据库进行了两项荟萃分析，并计算了标准平均差异。荟萃分析证实，在选定的大脑区域的突触丢失是AD发病机制的早期事件。对57个突触标记物的第二次荟萃分析显示，突触前标记物比突触后标记物受到更多的影响。目前的荟萃分析研究表明，整个大脑区域的突触丢失是一致的，分子机制，包括内体途径，囊泡组装机制，谷氨酸受体和轴突运输经常受到影响。
Loss of synapses best correlates to cognitive deficits in Alzheimer's disease (AD) in which oligomeric neurotoxic species of amyloid β appears to contribute synaptic pathology. While a number of clinical pathological studies have been performed with limited sample size, there are no systematic studies encompassing large samples. Therefore, we performed a meta-analysis study. We identified 417 publications reporting post-mortem synapse and synaptic marker loss from AD patients. Two meta-analyses were performed using a single database of sub-selected publications and calculating the standard mean differences. Meta-analysis confirmed synaptic loss in selected brain regions is an early event in AD pathogenesis. The second meta-analysis of 57 synaptic markers revealed that pre-synaptic makers were affected more than postsynaptic markers. The present meta-analysis study showed a consistent synaptic loss across brain regions and that molecular machinery including endosomal pathways, vesicular assembly mechanisms, glutamate receptors and axonal transport are often affected.
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影响因子：
4
作者：
Cao, Ying;Xiao, Yan;Guan, Zhi-Zhong
通讯作者：
Guan, Zhi-Zhong
影响因子：
3.3
作者：
Brady, DR;Mufson, EJ
通讯作者：
Mufson, EJ
DOI：
10.1016/0169-328x(95)00257-s
发表时间：
1996-02-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Cheetham, JE;Martzen, MR;Coleman, PD
通讯作者：
Coleman, PD
影响因子：
2.4
作者：
Bigio, EH;Reisch, JS;Bonte, FJ
通讯作者：
Bonte, FJ
影响因子：
9.9
作者：
Corey-Bloom, J;Tiraboschi, P;Thal, LJ
通讯作者：
Thal, LJ