Technological Advances of 3D Scaffold-Based Stem Cell/Exosome Therapy in Tissues and Organs.
Technological Advances of 3D Scaffold-Based Stem Cell/Exosome Therapy in Tissues and Organs.
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基于3D支架的干细胞/外泌体在组织器官中的治疗技术进展
DOI：
10.3389/fcell.2021.709204
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Gu C;Feng J;Waqas A;Deng Y;Zhang Y;Chen W;Long J;Huang S;Chen L
近年来，生物材料支架在组织工程和再生医学领域得到了广泛的应用。由于生产方法的不同，可以制造独特类型的三维（3D）支架，以满足组织和器官的结构特征，并提供合适的3D微环境。干细胞（SC）治疗在组织和器官中的治疗效果是相当可观的，并引起了世界各地学术研究人员的关注。然而，由于SC疗法的局限性和挑战，外泌体疗法可用于基础研究和临床转化。本文简要介绍了3D支架的材料（天然或聚合物）、形状（水凝胶、颗粒和多孔固体）和制造方法（交联或生物打印），并描述了近5年（2016 - 2020年）来3D支架在SC/外泌体治疗方面的最新进展。正常SC/外泌体治疗可以改善患病和受损组织和器官的结构和功能。此外，基于3D支架的SC/exosome疗法可以显著改善心脏和神经组织的结构和功能，用于治疗各种难治性疾病。此外，外泌体疗法与SC疗法具有相同的治疗效果，但没有缺点。因此，3D支架治疗为难治性和不治之症的治疗提供了一种替代策略，并已进入从基础研究到临床转化的转型期，成为未来可行的治疗选择。基于3D支架的干细胞/外泌体疗法的应用的概要示意图。
Recently, biomaterial scaffolds have been widely applied in the field of tissue engineering and regenerative medicine. Due to different production methods, unique types of three-dimensional (3D) scaffolds can be fabricated to meet the structural characteristics of tissues and organs, and provide suitable 3D microenvironments. The therapeutic effects of stem cell (SC) therapy in tissues and organs are considerable and have attracted the attention of academic researchers worldwide. However, due to the limitations and challenges of SC therapy, exosome therapy can be used for basic research and clinical translation. The review briefly introduces the materials (nature or polymer), shapes (hydrogels, particles and porous solids) and fabrication methods (crosslinking or bioprinting) of 3D scaffolds, and describes the recent progress in SC/exosome therapy with 3D scaffolds over the past 5 years (2016–2020). Normal SC/exosome therapy can improve the structure and function of diseased and damaged tissues and organs. In addition, 3D scaffold-based SC/exosome therapy can significantly improve the structure and function cardiac and neural tissues for the treatment of various refractory diseases. Besides, exosome therapy has the same therapeutic effects as SC therapy but without the disadvantages. Hence, 3D scaffold therapy provides an alternative strategy for treatment of refractory and incurable diseases and has entered a transformation period from basic research into clinical translation as a viable therapeutic option in the future. A summary schematic of application of 3D scaffold-based stem cell/exosome therapy.
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影响因子：
5.5
作者：
Feng J;Zhang Y;Zhu Z;Gu C;Waqas A;Chen L
通讯作者：
Chen L
影响因子：
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影响因子：
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作者：
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