Optical imaging probes in oncology.
Optical imaging probes in oncology.
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DOI：
10.18632/oncotarget.9066
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发表时间：
2016-07-26
期刊：
影响因子：
--
通讯作者：
Ottobrini L
中科院分区：
文献类型：
--
作者：
Martelli C;Lo Dico A;Diceglie C;Lucignani G;Ottobrini L
癌症是一种复杂的疾病，其特征是不同生理分子过程和细胞特征的改变。记住这一点，通过非侵入性方法早期识别和检测特定肿瘤生物标志物的可能性可以改善早期诊断和患者管理。不同的分子成像程序为肿瘤病变的检测和非侵入性表征提供了强大的工具。临床研究主要基于计算机断层扫描、核成像技术和磁共振成像的使用。小动物模型的临床前成像需要使用专用仪器，除了已经引用的成像技术之外，还包括光学成像研究。光学成像策略基于发光或荧光报告基因或可注射荧光或发光探针的使用，甚至可以通过荧光和发光成像来研究肿瘤特征。目前，这些探针大多数仅用于动物模型，但其中一些探针也应用于临床的可能性正在评估中。肿瘤成像的重要性、光学成像仪器的易用性、各种探针的商业可用性以及新开发的探针的不断描述，证明了这些应用的重要性。本综述的目的是提供对可用于肿瘤小鼠模型中肿瘤特征的非侵入性评估的可能光学成像程序的完整描述。特别是，将概述和讨论市售探针和新开发的探针的特性。
Cancer is a complex disease, characterized by alteration of different physiological molecular processes and cellular features. Keeping this in mind, the possibility of early identification and detection of specific tumor biomarkers by non-invasive approaches could improve early diagnosis and patient management. Different molecular imaging procedures provide powerful tools for detection and non-invasive characterization of oncological lesions. Clinical studies are mainly based on the use of computed tomography, nuclear-based imaging techniques and magnetic resonance imaging. Preclinical imaging in small animal models entails the use of dedicated instruments, and beyond the already cited imaging techniques, it includes also optical imaging studies. Optical imaging strategies are based on the use of luminescent or fluorescent reporter genes or injectable fluorescent or luminescent probes that provide the possibility to study tumor features even by means of fluorescence and luminescence imaging. Currently, most of these probes are used only in animal models, but the possibility of applying some of them also in the clinics is under evaluation. The importance of tumor imaging, the ease of use of optical imaging instruments, the commercial availability of a wide range of probes as well as the continuous description of newly developed probes, demonstrate the significance of these applications. The aim of this review is providing a complete description of the possible optical imaging procedures available for the non-invasive assessment of tumor features in oncological murine models. In particular, the characteristics of both commercially available and newly developed probes will be outlined and discussed.
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