Low catalyst loading in ring-closing metathesis reactions.
Low catalyst loading in ring-closing metathesis reactions.
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闭环复分解反应中催化剂负载量低。
作者：
R. Kadyrov
描述了一种有效的闭环复分解反应过程。在稀溶液中，二烯丙基丙二酸二乙酯的转化率可在几分钟内达到95%，TOF=4173NHCmin(-1)，并且含有不饱和 配体的商用Ru催化剂的负载量很低。一般来说，只需要50到250 ppm的催化剂就可以实现近乎定量的转化为各种5-16元杂环化合物。合成了5-8元N-叔丁氧基酮(N-Boc)和N-对甲苯磺酸(N-ts)保护的环胺和9-16元内酯，证明了该方法的实用性。合成大环脯氨酸内酰胺类化合物需要稍高的催化剂负载量。除单环产物外，还分离和鉴定了低聚副产物，主要是环二聚体。
An efficient procedure is described for ring-closing metathesis reactions. A conversion of 95% for diethyl diallylmalonate in dilute solution could be achieved within a few minutes, reaching TOF = 4173 min(-1), with very low loading of commercially available Ru catalysts that contained unsaturated NHC ligands. In general, only 50 to 250 ppm of the catalyst is required to achieve near-quantitative conversion into a broad variety of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-tert-butoxycarbonyl (N-Boc)- and N-para-toluenesulfonyl (N-Ts)-protected cyclic amines and 9-16-membered lactones. The synthesis of macrocyclic proline-based lactams required slightly higher catalyst loadings. Along with monocyclic products, oligomeric byproducts, mostly cyclodimers, were isolated and characterized.
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影响因子：
5.2
作者：
Kuhn KM;Champagne TM;Hong SH;Wei WH;Nickel A;Lee CW;Virgil SC;Grubbs RH;Pederson RL
通讯作者：
Pederson RL
4-C,3-O-丙烯连接的双环核苷的合成和生物学评价。
影响因子：
2.8
作者：
Hatton,Wilfried;Hunault,Julie;Egorov,Maxim;Len,Christophe;Pipelier,Muriel;Blot,Virginie;Silvestre,Virginie;Fargeas,Valérie;Ané,Adjou;McBrayer,Tami;Detorio,Mervi;Cho,Jong-Hyun;Bourgougnon,Nathalie;Dubreuil,Didier;Schinazi,Raymo
通讯作者：
Schinazi,Raymo
影响因子：
5.2
作者：
O'Doherty I;Yim JJ;Schmelz EA;Schroeder FC
通讯作者：
Schroeder FC
影响因子：
15
作者：
Thomas, Renee M.;Keitz, Benjamin K.;Champagne, Timothy M.;Grubbs, Robert H.
通讯作者：
Grubbs, Robert H.
影响因子：
15
作者：
Stewart, Ian C.;Keitz, Benjamin K.;Kuhn, Kevin M.;Thomas, Renee M.;Grubbs, Robert H.
通讯作者：
Grubbs, Robert H.