Alcohol‐related trafficking accidents
Alcohol‐related trafficking accidents
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与酒精有关的贩运事故
作者：
A. Diehl
细胞与细胞、细胞与间质的接触在调节组织的形态发生和分化功能中起着重要作用。这些过程中所涉及的分子机制的描绘是一个积极的调查领域。新出现的证据表明，粘附分子（例如，细胞表面的钙粘蛋白和钙非依赖性粘附分子）与其它细胞上的类似分子同嗜性结合。其它跨膜蛋白（例如，整联蛋白）连接细胞骨架元件（例如，talin，α-辅肌动蛋白）与细胞外基质的特定成分（例如，层粘连蛋白、纤连蛋白）。细胞-细胞粘附和细胞-基质粘附触发细胞骨架重排，这反过来调节细胞极性、生长和分化功能（1）。细胞骨架重排影响这些后一过程的机制仍然知之甚少。然而，最近的观察表明，profilin（一种膜相关肌动蛋白结合蛋白）也与肌醇二磷酸（PIP 21）结合，并影响磷脂酶C诱导的PIP 2水解为二酰基甘油，这表明细胞-细胞壳-基质接触、细胞骨架元件和膜磷脂启动的第二信使级联反应之间存在密切关系（2-4）。细胞-细胞和细胞-基质附着部位的细胞骨架改变也是质膜结构域发育的重要先决条件。质膜分离成结构上和功能上离散的区域对于肝细胞和其他极性上皮细胞的功能至关重要，这些细胞必须完成往返于其管腔（小管）和基底（窦）表面的定向运输。在细胞-细胞和细胞-基质附着部位的细胞骨架成分的凝聚似乎限制了蛋白质沿着膜的扩散，并将它们限制在特定的结构域。例如，富集细胞骨架蛋白锚蛋白和胞衬蛋白的细胞-基质附着位点将Na-K ATP酶锚定到基底（正弦）质膜结构域。这种附着防止了这种蛋白质的内吞作用和随后的细胞内降解，这通常发生在它插入某些上皮细胞的顶端（腔）膜结构域时（5-7）。一旦建立了特定的质膜结构域，其他蛋白质通过翻译后修饰选择性地靶向特定的质膜结构域（8）。例如，氨肽酶N和二肽酶IV是
Cell-to-cell and cell-to-stroma contacts play important roles in regulating the morphogenesis and differentiated functions of tissues. Delineation of the molecular mechanisms involved in these processes is an area of active investigation. Emerging evidence suggests that adhesion molecules (e.g., cadherins and calciumindependent adhesion molecules) on the surfaces of cells bind homophilically to similar molecules on other cells. Other transmembrane proteins (e.g., integrins) link cytoskeletal elements (e.g., talin, a-actinin) with specific constituents of the extracellular matrix (e.g., laminin, fibronectin). Cell-cell adhesion and cell-matrix adhesion trigger cytoskeletal rearrangements, which in turn modulate cellular polarity, growth and differentiated function (1). The mechanisms by which cytoskeletal rearrangements affect these latter processes remain poorly understood. However, the recent observation that profilin, a membrane-associated, actin-binding protein, also binds to inositol bis-phosphate (PIP21 and influences phospholipase C-induced hydrolysis of PIP2 to diacylglycerol suggests an intimate relationship between cell-cellhell-matrix contact, cytoskeletal elements and membrane phospholipid-initiated second messenger cascades (2-4). Cytoskeletal alterations at the site of cell-cell and cell-matrix attachments are also vital prerequisites for the development of plasma membrane domains. The separation of the plasma membrane into structurally and functionally discrete regions is vital for the function of hepatocytes and other polar epithelial cells that must accomplish directional transport to and from their luminal (canalicular) and basal (sinusoidal) surfaces. Condensation of cytoskeletal elements at the sites of cell-cell and cell-matrix attachments appears to restrict the diffusion of proteins along the membrane and limit them to specific domains. For example, enrichment of sites of cell-matrix attachment with the cytoskeletal proteins ankrin and fodrin anchors Na-K ATPase to the basal (sinusoidal) plasma membrane domain. The attachment prevents the endocytosis and subsequent intracellular degradation of this protein that typically occur when it is inserted into apical (luminal) membrane domains of certain epithelial cells (5-7). Once specific plasma membrane domains are established, other proteins are selectively targeted to particular plasma membrane domains by posttranslational modifications (8). For example, aminopeptidase N and dipeptidase IV are
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长期乙醇给药对灌注大鼠肝脏摄取和降解脱唾液酸糖蛋白的影响。
影响因子：
5.8
作者：
Casey,CA;Volentine,GD;Jankovich,CJ;Kragskow,SL;Tuma,DJ
通讯作者：
Tuma,DJ
影响因子：
15.9
作者：
BISSELL, DM;ARENSON, DM;ROLL, FJ
通讯作者：
ROLL, FJ
影响因子：
56.9
作者：
RODRIGUEZBOULAN, E;NELSON, WJ
通讯作者：
NELSON, WJ
影响因子：
2.8
作者：
HOEK, JB;RUBIN, E
通讯作者：
RUBIN, E
培养的大鼠肝细胞中白蛋白基因的转录调控。
DOI：
--
发表时间：
1990
期刊：
Molecular biology & medicine
影响因子：
--
作者：
Bissell,DM;Caron,JM;Babiss,LE;Friedman,JM
通讯作者：
Friedman,JM