PCB exposure and in vivo CYP1A2 activity among Native Americans.
PCB exposure and in vivo CYP1A2 activity among Native Americans.
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DOI：
10.1289/ehp.7370
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发表时间：
2005-03
影响因子：
10.4
通讯作者：
Tarbell A
中科院分区：
文献类型：
--
作者：
Fitzgerald EF;Hwang SA;Lambert G;Gomez M;Tarbell A
细胞色素 P-450 1A2 (CYP1A2) 是一种参与某些致癌物代谢激活的酶，据信是由异生素诱导的。然而，很少有研究调查环境暴露与人类体内 CYP1A2 活性之间的关联。为了解决这个问题，对因食用圣劳伦斯河鱼类而接触多氯联苯 (PCB) 的美洲原住民中的 CYP1A2 活性进行了一项研究。在 Akwesasne 的 Mohawk Nation（位于纽约、加拿大安大略省和魁北克省），103 名成年人接受了采访，他们捐献血液进行血清 PCB 分析，并接受咖啡因呼气测试 (CBT)，这是一种安全且无创的程序，使用咖啡因作为体内 CYP1A2 活性的探针。结果支持了其他研究的结果，即吸烟者和男性的 CBT 值较高，而使用口服避孕药的女性则较低。尽管该人群的平均总 PCB 身体负荷相对较低，但 9 种单邻位或双邻位取代的 PCB 同系物的血清水平总和显示与 CBT 值呈正相关（湿重 p = 0.052，脂质调整 p = 0.029），毒性当量也如此（TEQ；湿重 p = 0.091，脂质调整 p = 0.048）。对于个体同系物，PCB-153、PCB-170 和 PCB-180 的血清水平与 CBT 值显着相关。结果支持这样的观点：CYP1A2 活性可能是人类接触 PCB 的早期生物效应的标志，而 CBT 可能是监测此类效应的有用工具。
Cytochrome P-450 1A2 (CYP1A2) is an enzyme involved in the metabolic activation of some carcinogens and is believed to be induced by xenobiotics. Very few studies, however, have investigated the association between environmental exposures and in vivo CYP1A2 activity in humans. To address this issue, a study was conducted of CYP1A2 activity among Native Americans exposed to polychlorinated biphenyls (PCBs) from the consumption of fish from the St. Lawrence River. At the Mohawk Nation at Akwesasne (in New York and in Ontario and Quebec, Canada), 103 adults were interviewed, and they donated blood for serum PCB analysis and underwent the caffeine breath test (CBT), a safe and noninvasive procedure that uses caffeine as a probe for CYP1A2 activity in vivo. The results supported the findings of other studies that CBT values are higher among smokers and men and lower among women who use oral contraceptives. Despite a relatively low average total PCB body burden in this population, the sum of serum levels for nine mono- or di-ortho-substituted PCB congeners showed positive associations with CBT values (p = 0.052 wet weight and p = 0.029 lipid adjusted), as did toxic equivalent quantities (TEQs; p = 0.091 for wet weight and 0.048 for lipid adjusted). Regarding individual congeners, serum levels of PCB-153, PCB-170, and PCB-180 were significantly correlated with CBT values. The results support the notion that CYP1A2 activity may be a marker of an early biological effect of exposure to PCBs in humans and that the CBT may be a useful tool to monitor such effects.
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影响因子：
1.9
作者：
Fitzgerald, EF;Brix, KA;Tarbell, A
通讯作者：
Tarbell, A
影响因子：
6.7
作者：
CAMPBELL, ME;SPIELBERG, SP;KALOW, W
通讯作者：
KALOW, W
影响因子：
6.7
作者：
KALOW, W;TANG, BK
通讯作者：
TANG, BK
影响因子：
6.7
作者：
KALOW, W;TANG, BK
通讯作者：
TANG, BK
DOI：
10.1097/00008571-199206000-00003
发表时间：
1992-06-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
BUTLER, MA;LANG, NP;KADLUBAR, FF
通讯作者：
KADLUBAR, FF