Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence.
Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence.
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使用FlyExpress Discovery平台在多基因家族中进行胚胎表达的比较显示，比时间差异更大。
DOI：
10.1002/dvdy.22749
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发表时间：
2012-01
影响因子：
2.5
通讯作者：
Kumar, Sudhir
中科院分区：
文献类型：
--
作者：
Konikoff, Charlotte E.;Karr, Timothy L.;McCutchan, Michael;Newfeld, Stuart J.;Kumar, Sudhir
基因表达空间模式的重叠通常是胚胎发育过程中基因相互作用的初步线索。然而，人工检查图像需要大量的时间和资源，阻碍了重要交互的发现，因为有数以万计的图像存在。FlyExpress发现平台的开发是为了促进果蝇胚胎表达模式图像的数据驱动比较分析。在FlyExpress中对BDGP和Fly-FISH数据集进行的基于图像的搜索比基于文本的搜索产生更少但更精确的结果，当特定目标是寻找具有重叠表达模式的基因时。我们还提供了一个FlyExpress对科学发现的贡献的例子：对多基因家族成员的基因表达模式的分析表明，空间差异远比时间差异更频繁，特别是在母体向合子过渡之后。这一发现为重复基因获得新功能的分子机制提供了新的线索。
Overlaps in spatial patterns of gene expression are frequently an initial clue to genetic interactions during embryonic development. However, manual inspection of images requires considerable time and resources impeding the discovery of important interactions because tens of thousands of images exist. The FlyExpress discovery platform was developed to facilitate data-driven comparative analysis of expression pattern images from Drosophila embryos. An image-based search of the BDGP and Fly-FISH datasets conducted in FlyExpress yields fewer but more precise results than text-based searching when the specific goal is to find genes with overlapping expression patterns. We also provide an example of a FlyExpress contribution to scientific discovery: an analysis of gene expression patterns for multigene family members revealed that spatial divergence is far more frequent than temporal divergence, especially after the maternal to zygotic transition. This discovery provides a new clue to molecular mechanisms whereby duplicated genes acquire novel functions.
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