The increasing role of structural proteomics in cyanobacteria.

The increasing role of structural proteomics in cyanobacteria.
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DOI:
10.1042/ebc20220095
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发表时间:
2023-03-29
影响因子:
6.4
通讯作者:
--
中科院分区:
生物学2区
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--
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蓝细菌,也称为蓝绿藻,是地球上普遍存在的生物。它们含有生物技术行业及其他行业感兴趣的巨大蛋白质机械。最近,带注释的蓝细菌基因组的数量已经增加,使得对已知基因编码蛋白质的结构研究得以加速。本综述重点关注质谱 (MS) 的进展,这些进展使得能够对蓝细菌内的蛋白质和蛋白质复合物进行结构蛋白质组学研究。该评论还展示了 MS 揭示了蓝藻中这些非凡机器如何发挥作用背后的关键机制信息的例子。
Cyanobacteria, also known as blue–green algae, are ubiquitous organisms on the planet. They contain tremendous protein machineries that are of interest to the biotechnology industry and beyond. Recently, the number of annotated cyanobacterial genomes has expanded, enabling structural studies on known gene-coded proteins to accelerate. This review focuses on the advances in mass spectrometry (MS) that have enabled structural proteomics studies to be performed on the proteins and protein complexes within cyanobacteria. The review also showcases examples whereby MS has revealed critical mechanistic information behind how these remarkable machines within cyanobacteria function.
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