Interferon alpha on NZM2328.Lc1R27: enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure.
Interferon alpha on NZM2328.Lc1R27: enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure.
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DOI：
10.1016/j.clim.2014.06.008
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Fu SM
中科院分区：
文献类型：
--
作者：
Dai C;Wang H;Sung SS;Sharma R;Kannapell C;Han W;Wang Q;Davidson A;Gaskin F;Fu SM
干扰素α (IFNα)可能在系统性红斑狼疮（SLE）发病机制中发挥重要作用。最近的文献表明，IFNα与疾病活动无关，阻断IFNα对SLE治疗无效。本研究旨在进一步阐明IFNα在SLE中的作用。12周龄的NZM2328及其基因NZM2328。用腺病毒- ifn α (adeno-IFNα)或腺病毒- lacz （adeno-LacZ）攻毒雌性小鼠Lc1R27 （R27）。只有腺干扰素α治疗的NZM2328出现严重的蛋白尿，并死于慢性肾小球肾炎（GN）和终末期肾病。腺干扰素α处理的R27确实发生免疫复合物介导的GN，但肾功能正常。Adeno-LacZ处理的NZM2328显示肾小球增大，细胞增多，无免疫复合物沉积。Adeno-LacZ治疗的R27未出现血清学和组织学异常。腺干扰素α诱导NZM2328和R27抗dsdna和抗肾自身抗体。这些结果表明，终末器官损伤是宿主依赖性的，与自身免疫的关系较小，可能在SLE发病机制中具有重要意义。
Interferon alpha (IFNα) may play a significant role in systemic lupus erythematosus (SLE) pathogenesis. Recent literature suggests that IFNα does not correlate with disease activities and blockade of IFNα is not effective in treating SLE. This study aims to delineate further the role of IFNα in SLE. 12-week old NZM2328 and its congenic NZM2328.Lc1R27 (R27) female mice were challenged with adenovirus-IFNα (adeno-IFNα) or adenovirus-LacZ (adeno-LacZ). Only adeno-IFNα treated NZM2328 developed severe proteinuria and died of chronic glomerulonephritis (GN) and end stage renal disease. Adeno-IFNα treated R27 did develop immune complex-mediated GN but had normal renal function. Adeno-LacZ treated NZM2328 showed enlarged glomeruli and increased cellularity without immune complex deposition. Adeno-LacZ treated R27 did not show serological and histological abnormalities. Adeno-IFNα induced anti-dsDNA and anti-kidney autoantibodies in NZM2328 and R27. These results suggest that end organ damage is host-dependent and less related to autoimmunity and may have significant implications in SLE pathogenesis.
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DOI：
10.1084/jem.20130731
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ge Y;Jiang C;Sung SS;Bagavant H;Dai C;Wang H;Kannapell CC;Cathro HP;Gaskin F;Fu SM
通讯作者：
Fu SM
影响因子：
27.4
作者：
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通讯作者：
Wither, J.
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
Pascual V
DOI：
10.4049/jimmunol.1000466
发表时间：
2011-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jacob N;Guo S;Mathian A;Koss MN;Gindea S;Putterman C;Jacob CO;Stohl W
通讯作者：
Stohl W
影响因子：
2.6
作者：
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通讯作者：
Baechler E