Diagnostic utility of cerebral white matter integrity in early Alzheimer's disease.
Diagnostic utility of cerebral white matter integrity in early Alzheimer's disease.
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DOI：
10.3109/00207454.2010.494788
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Burns JM
中科院分区：
文献类型：
--
作者：
Johnson DK;Barrow W;Anderson R;Harsha A;Honea R;Brooks WM;Burns JM
我们比较了堪萨斯大学医学中心的一项关于衰老和记忆的纵向研究--脑老化项目中的健康对照组和患有非常轻度痴呆（临床痴呆评分0与0.5）的参与者的白色完整性与脑萎缩。对27例阿尔茨海默型（DAT）极轻度痴呆（临床痴呆评分= 0.5）患者和32例认知正常受试者进行了结构磁共振成像和弥散张量成像（DTI），包括各向异性分数和平均弥散度。在6个体积测量和14个DTI感兴趣区域对患者组进行比较。极轻度痴呆患者表现出预期的疾病相关脑萎缩模式，其中全脑和海马体积的减少最为突出。白色物质完整性的DTI指数混合。右侧海马旁各向异性分数显示出显著但较小的疾病相关性降低。右侧海马旁和左侧内囊表现出更大的平均扩散在早期DAT与对照组相比。一系列的判别分析表明，灰质萎缩是一个显着更好的预测痴呆状态比DTI指数。脑萎缩与非常轻微的DAT最密切相关。颞叶皮质中存在中度疾病相关的白色物质异常，深层白色物质的鉴别诊断能力有限，这可能是因为这些参与者的疾病处于非常轻微的阶段。
We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study of aging and memory at the University of Kansas Medical Center. Structural magnetic resonance imaging and diffusion tensor imaging (DTI) including fractional anisotropy and mean diffusivity were performed on 27 patients with very mild dementia (Clinical Dementia Rating = 0.5) of the Alzheimer's type (DAT), and 32 cognitively normal subjects. Patient groups were compared across 6 volumetric measures and 14 DTI regions of interest. Very mildly demented patients showed expected disease-related patterns of brain atrophy with reductions in whole-brain and hippocampal volumes most prominent. DTI indices of white matter integrity were mixed. Right parahippocampus showed significant but small disease-related reductions in fractional anisotropy. Right parahippocampus and left internal capsule showed greater mean diffusivity in early DAT compared with controls. A series of discriminant analyses demonstrated that gray matter atrophy was a significantly better predictor of dementia status than were DTI indices. Brain atrophy was most strongly related to very mild DAT. Modest disease-related white matter anomalies were present in temporal cortex, and deep white matter had limited discriminatory diagnostic power, probably because of the very mild stage of disease in these participants.
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影响因子：
9.9
作者：
Burns JM;Cronk BB;Anderson HS;Donnelly JE;Thomas GP;Harsha A;Brooks WM;Swerdlow RH
通讯作者：
Swerdlow RH
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
2.4
作者：
Englund, E
通讯作者：
Englund, E
影响因子：
4.2
作者：
Fellgiebel, A;Müller, MJ;Stoeter, P
通讯作者：
Stoeter, P
影响因子：
5.7
作者：
Müller, MJ;Greverus, D;Fellgiebel, A
通讯作者：
Fellgiebel, A