Effects of Helicobacter pylori treatment on the incidences of autoimmune diseases and inflammatory bowel disease in patients with diabetes mellitus.
Effects of Helicobacter pylori treatment on the incidences of autoimmune diseases and inflammatory bowel disease in patients with diabetes mellitus.
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DOI：
10.1371/journal.pone.0265323
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
已知幽门螺杆菌感染可降低自身免疫性疾病和炎症性肠病（IBD）的发病率。我们的目的是研究H.幽门螺杆菌治疗糖尿病（DM）患者。新诊断的H.成人。从2000 - 2010年台湾全民健康保险研究数据库中确定了一般人群和糖尿病人群中的幽门螺杆菌感染或消化性溃疡疾病（PUD）。79，181例患者被分配到3组：普通人群，PUD，无H。pylori治疗（普通人群PUD-HPRx）、PUD不伴H. pylori治疗（PUD-HPRx in DM）和PUD合并DM患者接受H.幽门螺杆菌治疗（PUD + HPRx在DM中）。糖尿病组PUD + HPRx组自身免疫性疾病和IBD的发生率高于普通人群PUD-HPRx组和糖尿病组PUD-HPRx组（自身免疫性疾病分别为5.14%、3.47%和3.65%; IBD分别为5.60%、3.17%和3.25%; P <0.0001）。糖尿病组PUD + HPRx组的全因死亡率（HR：0.937，P <0.001）低于糖尿病组PUD-HPRx组。与PUD-HPRx DM组相比，PUD + HPRx DM组中年轻患者的IBD发生率更高，死亡率更低。结果表明，H. pylori治疗增加了糖尿病PUD组自身免疫性疾病和IBD的发病率，降低了全因死亡率。这种效果在年轻患者中更为显著。这一发现有助于认识H.糖尿病人群中的幽门螺杆菌治疗。
Helicobacter pylori infection is known to decrease the incidences of autoimmune diseases and inflammatory bowel disease(IBD). Our aim was investigating the effect of H. pylori treatment in diabetes mellitus(DM) patients. Adults with newly-diagnosed H. pylori infection or peptic ulcer disease(PUD) within the general population and DM population were identified from the National Health Insurance Research Database of Taiwan from 2000–2010. 79,181 patients were assigned to the 3 groups: general population with PUD without H. pylori treatment(PUD-HPRx in general population), DM patients with PUD without H. pylori treatment(PUD-HPRx in DM), and DM patients with PUD who received H. pylori treatment(PUD+HPRx in DM). Higher incidences of autoimmune diseases and IBD were observed in the PUD+HPRx in DM group than in the PUD-HPRx in general population and PUD-HPRx in DM groups (autoimmune diseases = 5.14% vs 3.47% and 3.65%; IBD = 5.60% vs 3.17% and 3.25%; P<0.0001). A lower all-cause mortality was noted in the PUD+HPRx in DM group (HR: 0.937, P<0.001) than in the PUD-HPRx in DM group. Trends of a higher incidence of IBD and a lower mortality in younger patients in the PUD+HPRx in DM group compared with the PUD-HPRx in DM group were noted. The results revealed that H. pylori treatment increased the incidences of autoimmune diseases and IBD and decreased the all-cause mortality in the DM group with PUD. The effect was more significant in younger patients. This finding assists in realizing the influence of H. pylori treatment in the DM population.
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DOI：
10.1111/j.1365-2362.2008.01951.x
发表时间：
2008-06-01
影响因子：
5.5
作者：
Hsu, P. I.;Wu, D. C.;Lai, K. H.
通讯作者：
Lai, K. H.
影响因子：
1.2
作者：
Fialho, Andre;Fialho, Andrea;De Melo, Silvio W., Jr.
通讯作者：
De Melo, Silvio W., Jr.
影响因子：
4.3
作者：
Papamichael, Konstantinos;Konstantopoulos, Panagiotis;Mantzaris, Gerassimos J.
通讯作者：
Mantzaris, Gerassimos J.
影响因子：
4.3
作者：
Dai, Yi-Ning;Yu, Wei-Lai;Li, You-Ming
通讯作者：
Li, You-Ming
影响因子：
3.3
作者：
Ranjbar, Reza;Karampoor, Sajad;Jalilian, Farid Azizi
通讯作者：
Jalilian, Farid Azizi