Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells.
Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cells.
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DOI：
10.1615/critrevimmunol.v32.i1.50
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发表时间：
2012
影响因子：
1.3
通讯作者：
Laird RM
中科院分区：
文献类型：
--
作者：
Hayes SM;Laird RM
大多数效应T细胞在遇到外源抗原并暴露于可溶性和膜结合介质后在外周中产生。然而，有一些T细胞亚群，如γδ T细胞和自然杀伤T细胞，在它们迁移到外周之前在胸腺中获得它们的效应子潜能。这种发育预编程使这些细胞能够在宿主免疫应答期间迅速分化为产生精氨酸的效应物。本文综述了小鼠产生白细胞介素（IL）-17的γδ T（γδ-17）细胞，这些细胞通过早期产生IL-17而在多种感染性和自身免疫性疾病中发挥关键作用。具体来说，我们讨论了目前已知的遗传要求，他们的一代，并比较它与已知的更广泛的研究IL-17产生辅助T（Th 17）细胞。基于这种比较，我们提出了小鼠γδ-17发育和分化的模型。
Most effector T cells are generated in the periphery following an encounter with a foreign antigen and exposure to soluble and membrane-bound mediators. There are, however, some T cell subsets, such as γδ T cells and natural killer T cells, that acquire their effector potential in the thymus before their emigration to the periphery. This developmental preprogramming enables these cells to differentiate rapidly into cytokine-producing effectors during the host immune response. This review focuses on murine interleukin (IL)-17–producing γδ T (γδ-17) cells, which have been shown, through their early production of IL-17, to have a critical role in multiple infectious and autoimmune diseases. Specifically, we discuss what is currently known about the genetic requirements for their generation and compare it with what is known about that of the more extensively studied IL-17–producing helper T (Th17) cells. Based on this comparison, we propose a model for murine γδ-17 development and differentiation.
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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