TRPV1: A Potential Drug Target for Treating Various Diseases.
TRPV1: A Potential Drug Target for Treating Various Diseases.
复制标题
DOI：
10.3390/cells3020517
复制
发表时间：
2014-05-23
期刊：
影响因子：
6
通讯作者：
Ramkumar V
中科院分区：
文献类型：
--
作者：
Brito R;Sheth S;Mukherjea D;Rybak LP;Ramkumar V
瞬时受体电位香草酸1（TRPV1）是存在于感觉神经元上的离子通道，其被热、质子、辣椒素和称为内香草酸的多种内源性脂质激活。因此，TRPV1可作为伤害性刺激的多模式传感器，其可触发对抗措施以避免疼痛和损伤。TRPV1的激活与慢性炎性疼痛和周围神经病变有关，如在糖尿病中观察到的。TRPV1的表达也在非神经元部位如膀胱和肺的上皮以及耳蜗的毛细胞中观察到。在这些部位，TRPV1的激活与膀胱炎、哮喘和听力损失等疾病的病理生理学有关。因此，可以调节TRPV1通道活性的药物可能有助于治疗从慢性疼痛到听力损失的疾病。本文综述了TRPV1在身体特定器官的正常生理和病理生理中的作用，并强调了靶向该通道的药物在临床上的重要性。
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. As such, TRPV1 serves as a multimodal sensor of noxious stimuli which could trigger counteractive measures to avoid pain and injury. Activation of TRPV1 has been linked to chronic inflammatory pain conditions and peripheral neuropathy, as observed in diabetes. Expression of TRPV1 is also observed in non-neuronal sites such as the epithelium of bladder and lungs and in hair cells of the cochlea. At these sites, activation of TRPV1 has been implicated in the pathophysiology of diseases such as cystitis, asthma and hearing loss. Therefore, drugs which could modulate TRPV1 channel activity could be useful for the treatment of conditions ranging from chronic pain to hearing loss. This review describes the roles of TRPV1 in the normal physiology and pathophysiology of selected organs of the body and highlights how drugs targeting this channel could be important clinically.
登录
查看更多内容
DOI：
10.1016/j.bbrc.2004.06.149
发表时间：
2004-08-11
影响因子：
3.1
作者：
Akiba, Y;Kato, S;Hibi, T
通讯作者：
Hibi, T
影响因子：
4.8
作者：
Chu, CJ;Huang, SM;Walker, JM
通讯作者：
Walker, JM
DOI：
10.1073/pnas.0407780102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Basu, S;Srivastava, P
通讯作者：
Srivastava, P
DOI：
10.1152/ajpregu.1999.277.3.r786
发表时间：
1999-09-01
影响因子：
2.8
作者：
Cheng, CL;Liu, JC;De Groat, WC
通讯作者：
De Groat, WC
影响因子：
2.9
作者：
CHENG, CL;MA, CP;DEGROAT, WC
通讯作者：
DEGROAT, WC