Damage to the dorsolateral prefrontal cortex is associated with repetitive compulsive behaviors in patients with penetrating brain injury.
Damage to the dorsolateral prefrontal cortex is associated with repetitive compulsive behaviors in patients with penetrating brain injury.
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DOI：
10.1136/bmjno-2021-000229
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发表时间：
2022
影响因子：
2.7
通讯作者：
Grafman, Jordan
中科院分区：
文献类型：
--
作者：
Fremont, Rachel;Dworkin, Jordan;Manoochehri, Masood;Krueger, Frank;Huey, Edward;Grafman, Jordan
皮质-纹状体-丘脑-皮质 (CSTC) 回路的损伤与动物和人类重复行为的发展有关。然而，这些结构受伤后形成的重复行为的类型尚不清楚。这项研究探讨了越南战争退伍军人的 CSTC 回路各个元件受到的损害对强迫症、强迫症和抽动症的影响。我们对 CSTC 环路特定要素（外侧和内侧眶额和背外侧前额皮质、前扣带皮层、丘脑和基底神经节）中创伤性脑损伤造成的体积损失与耶鲁-布朗强迫症量表症状检查表和耶鲁全球抽动严重程度的修订版分数之间进行了部分相关（校正认知、年龄、教育和整体脑损伤）。对 83 名越南战争退伍军人进行了测量，他们的大脑不同部位都受到了穿透性脑损伤。我们发现，左侧背外侧前额叶皮层的体积损失与强迫行为的发生有关（r=0.32，padj<0.05），而基底神经节的体积损失与抽动的发生相关（r=0.33，padj<0.05）。我们的研究结果表明，特定 CSTC 元素的损害可能与强迫行为和抽动的发展有关，而这些行为和抽动不一定伴随着强迫行为。
Damage to cortico-striato-thalamo-cortical (CSTC) circuits is associated with the development of repetitive behaviours in animals and humans. However, the types of repetitive behaviours that are developed after injury to these structures are poorly defined. This study examines the effect of damage to separate elements of CSTC circuits sustained by veterans of the Vietnam War on obsessions, compulsions, and tics. We performed partial correlations (correcting for cognition, age, education, and global brain damage) between volume loss from traumatic brain injury in specific elements of CSTC circuits (lateral and medial orbitofrontal and dorsolateral prefrontal cortices, anterior cingulate cortex, thalamus, and basal ganglia) and scores on a modified version of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist and the Yale Global Tic Severity Scale in 83 Vietnam war veterans with penetrating brain injuries at different sites throughout the brain. We found that volume loss in the left dorsolateral prefrontal cortex was associated with the development of compulsive behaviours (r=0.32, padj<0.05) whereas volume loss in the basal ganglia was associated with the development of tics (r=0.33, padj<0.05). Our findings indicate that damage to specific CSTC elements can be associated with the development of compulsive behaviours and tics that are not necessarily accompanied by obsessions.
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