The interactive effects of ketamine and nicotine on human cerebral blood flow.
The interactive effects of ketamine and nicotine on human cerebral blood flow.
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DOI：
10.1007/s00213-009-1758-2
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发表时间：
2010-03
影响因子：
3.4
通讯作者：
Holcomb, Henry H.
中科院分区：
文献类型：
--
作者：
Rowland, Laura M.;Beason-Held, Lori;Tamminga, Carol A.;Holcomb, Henry H.
本研究的目的是确定急性尼古丁是否减弱氯胺酮诱导的局部脑血流量（rCBF）。尼古丁戒断2-4小时后，健康的慢性吸烟者参加了四组rCBF研究，H215 O正电子发射断层扫描，在一个简单的感觉运动控制任务。研究的四种药物条件为安慰剂、氯胺酮单独给药、尼古丁单独给药和氯胺酮+尼古丁。静脉注射氯胺酮可增加额叶、眶额和前扣带回区域的rCBF。尼古丁单独诱导外侧枕叶皮质rCBF显著升高，基底节和前扣带皮质rCBF升高。尼古丁加氯胺酮减弱氯胺酮诱导的前扣带皮层rCBF升高，但导致眶额区rCBF显著增加。本研究阐明了氯胺酮（一种NMDA受体拮抗剂）和尼古丁在多个脑区的相互作用。尼古丁显著改善氯胺酮对前扣带回rCBF的影响，单独给药时，显著抑制前扣带回rCBF。氯胺酮和尼古丁共同观察到的增强的协同眶额效应表明，大脑区域中的兴奋性神经传递显著增加，通常与精神病、奖励和成瘾行为有关。
The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF). Following 2–4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H215O positron emission tomography, during a simple sensory motor control task. The four drug conditions studied were placebo, ketamine alone, nicotine alone, and ketamine+nicotine. Intravenous ketamine increased rCBF in frontal, orbital–frontal, and anterior cingulate areas. Nicotine alone induced marked rCBF elevations in the lateral occipital cortex and rCBF suppressions in the basal ganglia and anterior cingulate cortex. Nicotine added to ketamine attenuated the ketamine-induced elevated rCBF in the anterior cingulate cortex but caused a marked rCBF increase in the orbital frontal region. This study illustrates the interactive effects of ketamine, an NMDA receptor antagonist, and nicotine in multiple brain regions. Nicotine substantially ameliorated the effects of ketamine on anterior cingulate rCBF and, when given alone, markedly suppressed anterior cingulate rCBF. The enhanced, synergistic orbitofrontal effects observed with ketamine and nicotine together suggest a marked increase in excitatory neurotransmission in a brain region often linked to psychosis, reward, and addictive behaviors.
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DOI：
10.1196/annals.1300.008
发表时间：
2003-01-01
期刊：
GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION
影响因子：
--
作者：
Farber, NB
通讯作者：
Farber, NB
影响因子：
6.1
作者：
Deutsch, SI;Rosse, RB;Mastropaolo, J
通讯作者：
Mastropaolo, J
影响因子：
56.9
作者：
Jentsch, JD;Redmond, DE;Roth, RH
通讯作者：
Roth, RH
影响因子：
7.6
作者：
Dépatie, L;O'Driscoll, GA;Lal, S
通讯作者：
Lal, S
影响因子：
3.4
作者：
Krystal, JH;D'Souza, DC;Hoffman, R
通讯作者：
Hoffman, R