Direct arylation and heterogeneous catalysis; ever the twain shall meet.
Direct arylation and heterogeneous catalysis; ever the twain shall meet.
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DOI：
10.1039/c5sc01534k
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发表时间：
2015-10-01
期刊：
影响因子：
8.4
通讯作者：
McGlacken GP
中科院分区：
文献类型：
--
作者：
Cano R;Schmidt AF;McGlacken GP
我们将成熟但知之甚少的多相催化主题与快速扩展的直接芳基化领域结合在一起，以期加速催化剂设计和对催化剂行为的理解。芳基-芳基键和杂芳基类似物的形成是有机化学中最重要的C-C键形成过程之一。最近，一种称为直接芳基化 (DA) 的方法已成为传统交叉偶联反应（Suzuki-Miyaura、Stille、Negishi 等）的有吸引力的替代方案。制药和其他化学工业的一个共同关注点是使用多相催化作为交叉偶联反应中均相催化的有利替代品。直到最近，多相催化才被提出并应用于 DA 反应。从这个角度来看，我们考虑术语“多相”和“均相”以及与它们在过渡金属催化反应中的描述相关的问题。我们重点介绍了 DA 和多相催化界面的报告，并简要评论了尝试将反应类型分类为均相或异相的方法。在未来的工作中，我们建议重点关注动力学方法，它为分析提供了良好的平台。此外，还描述了两种分析技术，如果将其开发用于 DA 反应原位运行，将阐明我们对催化的理解。总的来说，我们提供了一个切入点，将成熟但知之甚少的多相催化主题与快速扩展的DA领域结合在一起，以期加速催化剂设计和对催化剂行为的理解。
We bring together the mature, yet poorly-understood, subject of heterogeneous catalysis with the rapidly expanding area of Direct Arylation, with a view towards the acceleration of catalyst design and the understanding of catalyst behaviour. The formation of aryl–aryl bonds and heteroaryl analogues is one of the most important C–C bond forming processes in organic chemistry. Recently, a methodology termed Direct Arylation (DA) has emerged as an attractive alternative to traditional cross-coupling reactions (Suzuki–Miyaura, Stille, Negishi, etc.). A parallel focus of the pharmaceutical and other chemical industries has been on the use heterogeneous catalysis as a favourable substitute for its homogeneous counterpart in cross-coupling reactions. Only very recently has heterogeneous catalysis been proposed and applied, to DA reactions. In this perspective, we consider the terms ‘heterogeneous’ and ‘homogeneous’ and the problems associated with their delineation in transition-metal catalysed reactions. We highlight the reports at the interface of DA and heterogeneous catalysis and we comment briefly on the methods used which attempt to classify reaction types as homo- or heterogeneous. In future work we recommend an emphasis be placed on kinetic methods which provide an excellent platform for analysis. In addition two analytical techniques are described which if developed to run in situ with DA reactions would illuminate our understanding of the catalysis. Overall, we provide an entry point, and bring together the mature, yet poorly-understood, subject of heterogeneous catalysis with the rapidly expanding area of DA, with a view towards the acceleration of catalyst design and the understanding of catalyst behaviour.
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影响因子：
15
作者：
Carrow, Brad P.;Hartwig, John. F.
通讯作者：
Hartwig, John. F.
影响因子：
3.9
作者：
Keshipour, Sajjad;Shaabani, Ahmad
通讯作者：
Shaabani, Ahmad
影响因子：
9.8
作者：
Constable, David J. C.;Dunn, Peter J.;Zhang, Tony Y.
通讯作者：
Zhang, Tony Y.
影响因子：
1.8
作者：
Cusati, Giuseppe;Djakovitch, Laurent
通讯作者：
Djakovitch, Laurent
DOI：
10.1016/s0020-1693(00)83716-0
发表时间：
1981-01-01
期刊：
INORGANICA CHIMICA ACTA-ARTICLES
影响因子：
--
作者：
HALPERN, J
通讯作者：
HALPERN, J