Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China
Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China
复制标题
中国回顾性队列抗结核治疗期间定期监测肝功能的效果
DOI：
10.1186/1471-2458-12-454
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发表时间：
2012-06
影响因子：
4.5
通讯作者：
Cheng, Shiming
中科院分区：
文献类型：
--
作者：
Zhan, Siyan;Xia, Yinyin;Lv, Xiaozhen;Zhang, Yuan;Tang, Shaowen;Yang, Zhirong;Tu, Dehua;Deng, Peiyuan;Cheng, Shiming
BackgroundData on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment.MethodsA retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis.Results33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001).ConclusionsScheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment.
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影响因子：
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作者：
Lange, Christoph;Kalsdorf, Barbara;Heyckendorf, Jan
通讯作者：
Heyckendorf, Jan
DOI：
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发表时间：
2006
期刊：
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影响因子：
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作者：
J. Saukkonen;D. Cohn;R. Jasmer;S. Schenker;J. Jereb;C. Nolan;C. Peloquin;F. Gordin;D. Nunes;D. Strader;J. Bernardo;R. Venkataramanan;T. Sterling
通讯作者：
J. Saukkonen;D. Cohn;R. Jasmer;S. Schenker;J. Jereb;C. Nolan;C. Peloquin;F. Gordin;D. Nunes;D. Strader;J. Bernardo;R. Venkataramanan;T. Sterling
DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
通讯作者：
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DOI：
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发表时间：
2001-05
期刊：
The National medical journal of India
影响因子：
--
作者：
M. Thakur
通讯作者：
M. Thakur
影响因子：
81.5
作者：
Pai, Madhukar;Behr, Marcel A.;Raviglione, Mario
通讯作者：
Raviglione, Mario