Making the case: married versus separate models of alphaherpes virus anterograde transport in axons.
Making the case: married versus separate models of alphaherpes virus anterograde transport in axons.
复制标题
DOI：
10.1002/rmv.1724
复制
发表时间：
2012-11
影响因子：
11.1
通讯作者：
Enquist, L. W.
中科院分区：
文献类型：
--
作者：
Kratchmarov, R.;Taylor, M. P.;Enquist, L. W.
甲型疱疹病毒病毒粒子感染神经元，并在轴突中运输，在宿主神经系统内远距离传播。新合成的疱疹病毒颗粒在轴突顺行运输过程中的聚集状态是甲型疱疹病毒生物学中的一个基本问题。在过去的二十年里，这种颗粒的结构仍然难以捉摸，也一直存在争议，来自EM、免疫荧光和活细胞成像研究的证据相互矛盾。人们提出了两种截然相反的模式--已婚和分居模式。在已婚模型中，传染性病毒粒子先在神经元细胞体中组装，然后分类成轴突，然后在运输小泡中运输。相反，单独的模型假设，含有病毒膜蛋白的囊泡独立于衣壳被分选到轴突中，成熟病毒粒子的最终组装发生在远处的出口部位。最近，一系列使用高分辨率EM和活细胞荧光显微镜的互补研究提供了与已婚模式一致的证据，而其他研究则提供了支持单独模式的证据。在这篇综述中，我们比较和讨论已发表的数据，并试图协调不同的发现和解释，因为它们与这些模型有关。
Alphaherpesvirus virions infect neurons and are transported in axons for long distance spread within the host nervous system. The assembly state of newly made herpesvirus particles during anterograde transport in axons is an essential question in alphaherpesvirus biology. The structure of the particle has remained both elusive and controversial for the past two decades, with conflicting evidence from EM, immunofluorescence, and live cell imaging studies. Two opposing models have been proposed—the Married and Separate Models. Under the Married Model, infectious virions are assembled in the neuronal cell body before sorting into axons and then traffic inside a transport vesicle. Conversely, the Separate Model postulates that vesicles containing viral membrane proteins are sorted into axons independent of capsids, with final assembly of mature virions occurring at a distant egress site. Recently, a complementary series of studies employing high-resolution EM and live cell fluorescence microscopy have provided evidence consistent with the Married Model, whereas other studies offer evidence supporting the Separate Model. In this review, we compare and discuss the published data and attempt to reconcile divergent findings and interpretations as they relate to these models.
登录
查看更多内容
影响因子：
3.8
作者：
HILL, TJ;FIELD, HJ
通讯作者：
FIELD, HJ
影响因子：
5.4
作者：
Antinone, Sarah E.;Zaichick, Sofia V.;Smith, Gregory A.
通讯作者：
Smith, Gregory A.
轴突运输过程中单纯疱疹病毒的冷冻电子断层扫描和原发性神经元中的次级包膜。
影响因子：
6.7
作者：
Ibiricu I;Huiskonen JT;Döhner K;Bradke F;Sodeik B;Grünewald K
通讯作者：
Grünewald K
影响因子：
3.7
作者：
Huang J;Lazear HM;Friedman HM
通讯作者：
Friedman HM
影响因子：
3.8
作者：
Dasgupta, A;Wilson, DW
通讯作者：
Wilson, DW