Striatal circuits, habits, and implications for obsessive-compulsive disorder.
Striatal circuits, habits, and implications for obsessive-compulsive disorder.
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DOI：
10.1016/j.conb.2014.08.008
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发表时间：
2015-02
影响因子：
5.7
通讯作者：
Graybiel AM
中科院分区：
文献类型：
--
作者：
Burguière E;Monteiro P;Mallet L;Feng G;Graybiel AM
越来越多的证据表明皮质纹状体回路异常与强迫症 (OCD) 和 OC 谱系疾病的病理生理学有关。重复性强迫行为的出现与自动化行为的获得之间的相似之处表明，强迫行为的表达可能部分涉及对此类习惯行为的失控。人类成像和其他证据、与强迫症综合征相关基因的发现以及这些疾病动物模型的功能研究都强化了纹状体回路功能障碍与 OC 谱系疾病有关的观点。我们强调遗传学和神经生物学工作的日益一致性，表明额纹状体回路及其与基底神经节、丘脑和脑干的联系是强迫症治疗干预的有希望的候选者。
Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.
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