Daily sitting time and all-cause mortality: a meta-analysis.
Daily sitting time and all-cause mortality: a meta-analysis.
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DOI：
10.1371/journal.pone.0080000
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
van der Ploeg HP
中科院分区：
文献类型：
--
作者：
Chau JY;Grunseit AC;Chey T;Stamatakis E;Brown WJ;Matthews CE;Bauman AE;van der Ploeg HP
量化每日总坐姿与全因死亡风险之间的相关性，并在调整和不调整中度至剧烈体力活动的情况下检查剂量反应关系。1989年至2013年1月发表的研究通过检索多个数据库、坐姿与健康系统综述的参考文献列表以及作者个人文献数据库进行识别。我们纳入了前瞻性队列研究，这些研究将每日总坐着时间作为定量暴露变量，全因死亡率作为结局，并报告了相对风险的估计值，或比值比或风险比（95%置信区间）。两位作者独立提取数据，并使用随机效应模型计算关联的汇总估计值。纳入了6项研究，涉及595，086名成人和29，162例死亡的数据，随访时间为3，565，569人年。研究参与者主要是来自高收入国家的女性、中年或老年人;平均研究质量评分为12/15分。每日总坐着时间和全因死亡率之间的关系不是线性的。调整体力活动后，最佳拟合样条模型的剂量反应HR为1.00（95% CI：0.98 - 1.03），1.02（95% CI：0.99 - 1.05）和1.05（95% CI：1.02 - 1.08）分别为0 - 3、> 3 - 7和> 7小时/天总坐位间隔的坐位时间每增加1小时。该模型估计，在考虑身体活动后，每天坐10小时的成年人的死亡风险高出34%。调整体力活动后，每日总坐姿时间的全因死亡率的总体加权人群归因分数为5.9%。每日总坐着的时间越长，全因死亡的风险越大，而中度至剧烈的体力活动似乎可以减轻这种危险。这些发现为确定一个阈值提供了一个起点，除了身体活动指南之外，该阈值还可以作为临床和公共卫生建议的基础。
To quantify the association between daily total sitting and all-cause mortality risk and to examine dose-response relationships with and without adjustment for moderate-to-vigorous physical activity. Studies published from 1989 to January 2013 were identified via searches of multiple databases, reference lists of systematic reviews on sitting and health, and from authors’ personal literature databases. We included prospective cohort studies that had total daily sitting time as a quantitative exposure variable, all-cause mortality as the outcome and reported estimates of relative risk, or odds ratios or hazard ratios with 95% confidence intervals. Two authors independently extracted the data and summary estimates of associations were computed using random effects models. Six studies were included, involving data from 595,086 adults and 29,162 deaths over 3,565,569 person-years of follow-up. Study participants were mainly female, middle-aged or older adults from high-income countries; mean study quality score was 12/15 points. Associations between daily total sitting time and all-cause mortality were not linear. With physical activity adjustment, the spline model of best fit had dose-response HRs of 1.00 (95% CI: 0.98-1.03), 1.02 (95% CI: 0.99-1.05) and 1.05 (95% CI: 1.02-1.08) for every 1-hour increase in sitting time in intervals between 0-3, >3-7 and >7 h/day total sitting, respectively. This model estimated a 34% higher mortality risk for adults sitting 10 h/day, after taking physical activity into account. The overall weighted population attributable fraction for all-cause mortality for total daily sitting time was 5.9%, after adjusting for physical activity. Higher amounts of daily total sitting time are associated with greater risk of all-cause mortality and moderate-to-vigorous physical activity appears to attenuate the hazardous association. These findings provide a starting point for identifying a threshold on which to base clinical and public health recommendations for overall sitting time, in addition to physical activity guidelines.
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影响因子：
18.4
作者：
Chau, Josephine Y.;Grunseit, Anne;Van der Ploeg, Hidde P.
通讯作者：
Van der Ploeg, Hidde P.
影响因子：
4.1
作者：
Matthews CE;Hagströmer M;Pober DM;Bowles HR
通讯作者：
Bowles HR
影响因子：
5
作者：
Matthews, Charles E.;Chen, Kong Y.;Troiano, Richard P.
通讯作者：
Troiano, Richard P.
影响因子：
7.1
作者：
Matthews, Charles E.;George, Stephanie M.;Schatzkin, Arthur
通讯作者：
Schatzkin, Arthur
影响因子：
3.7
作者：
Koster A;Caserotti P;Patel KV;Matthews CE;Berrigan D;Van Domelen DR;Brychta RJ;Chen KY;Harris TB
通讯作者：
Harris TB