Harnessing Nanotopography to Enhance Osseointegration of Clinical Orthopedic Titanium Implants-An in Vitro and in Vivo Analysis.
Harnessing Nanotopography to Enhance Osseointegration of Clinical Orthopedic Titanium Implants-An in Vitro and in Vivo Analysis.
复制标题
DOI：
10.3389/fbioe.2018.00044
复制
发表时间：
2018
影响因子：
5.7
通讯作者：
Oreffo ROC
中科院分区：
文献类型：
--
作者：
Goriainov V;Hulsart-Billstrom G;Sjostrom T;Dunlop DG;Su B;Oreffo ROC
尽管技术不断进步，但骨科和骨再生领域的进一步创新对于满足日益老龄化的人口日益增长的需求以及相关的疾病，损伤和创伤问题至关重要。纳米形貌为新型植入物表面改性提供了新的机会，并有望进一步改善植入物性能。然而，纳米形貌制造和表面分析的技术复杂性已经排除了触发成骨的最佳表面特征的识别。我们在此详细介绍了离散纳米点和纳米线纳米形貌的骨诱导潜力。我们研究了改性钛和钛合金（Ti64）表面在体外诱导人骨骼干细胞（SSC）中骨特异性基因激活和细胞外基质蛋白表达的能力，以及在体内小鼠颅骨模型中的从头成骨反应。这项研究提供了证据，增强成骨反应纳米线300表面改性，具有重要意义的临床骨科应用。
Despite technological advancements, further innovations in the field of orthopedics and bone regeneration are essential to meet the rising demands of an increasing aging population and associated issues of disease, injury and trauma. Nanotopography provides new opportunities for novel implant surface modifications and promises to deliver further improvements in implant performance. However, the technical complexities of nanotopography fabrication and surface analysis have precluded identification of the optimal surface features to trigger osteogenesis. We herein detail the osteoinductive potential of discrete nanodot and nanowire nanotopographies. We have examined the ability of modified titanium and titanium alloy (Ti64) surfaces to induce bone-specific gene activation and extracellular matrix protein expression in human skeletal stem cells (SSCs) in vitro, and de novo osteogenic response within a murine calvarial model in vivo. This study provides evidence of enhanced osteogenic response to nanowires 300 surface modifications, with important implications for clinical orthopedic application.
登录
查看更多内容
影响因子：
4.6
作者：
Diu T;Faruqui N;Sjöström T;Lamarre B;Jenkinson HF;Su B;Ryadnov MG
通讯作者：
Ryadnov MG
DOI：
10.1073/pnas.94.3.849
发表时间：
1997-02-04
影响因子：
11.1
作者：
Maniotis, AJ;Chen, CS;Ingber, DE
通讯作者：
Ingber, DE
影响因子：
14
作者：
Hollander, DA;von Walter, M;Erli, HJ
通讯作者：
Erli, HJ
影响因子：
14
作者：
Lee LC;Gadegaard N;de Andrés MC;Turner LA;Burgess KV;Yarwood SJ;Wells J;Salmeron-Sanchez M;Meek D;Oreffo RO;Dalby MJ
通讯作者：
Dalby MJ
影响因子：
5.4
作者：
Biggs, Manus Jonathan Paul;Richards, R. Geoff;Dalby, Matthew J.
通讯作者：
Dalby, Matthew J.